333986-70-2

Usage

Uses

Used in Pharmaceutical Industry:
4-PIPERIDIN-4-YLMETHYL-BENZOIC ACID METHYL ESTER HCL is used as an intermediate in the synthesis of various drugs and pharmaceuticals for its stability and solubility properties.
Used in Antipsychotic Medications:
4-PIPERIDIN-4-YLMETHYL-BENZOIC ACID METHYL ESTER HCL is used as a key component in the development of antipsychotic medications, contributing to their efficacy in treating mental health disorders.
Used in Antihistaminic Medications:
4-PIPERIDIN-4-YLMETHYL-BENZOIC ACID METHYL ESTER HCL is utilized in the formulation of antihistaminic drugs, helping to alleviate symptoms associated with allergies and other hypersensitivity reactions.
Used in Neuroprotective Research:
4-PIPERIDIN-4-YLMETHYL-BENZOIC ACID METHYL ESTER HCL is used as a subject of study for its potential neuroprotective properties, aiming to develop treatments for neurological disorders.
Used in Anti-inflammatory Research:
4-PIPERIDIN-4-YLMETHYL-BENZOIC ACID METHYL ESTER HCL is employed in research exploring its anti-inflammatory potential, which could lead to advancements in the treatment of inflammatory conditions.
Used in Protein Structure and Function Analysis:
4-PIPERIDIN-4-YLMETHYL-BENZOIC ACID METHYL ESTER HCL is used as a tool in biological systems to determine the structure and function of certain proteins, aiding in a better understanding of their roles in health and disease.

Upstream product

• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 14295-52-4 4-(diethyoxyphosphorylmethyl)benzoic acid methyl ester 
• 210964-04-8 tert-Butyl 4-(4-methoxycarbonylbenzyl)piperidine-1-carboxylate 
• 209808-15-1 4-(4-methoxycarbonylbenzylidene)piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1400797-44-5 4-{1-[(S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzyl]-piperidin-4-ylmethyl}-benzoic acid methyl ester 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

Cyclic amine compounds as CCR5 antagonists

A compound of formula (I) (wherein R1is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R2is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, or R1and R2may combine to each other together with A to form a heterocyclic group which may be substituted; A is N or N+—R5.Y?(R5is a hydrocarbon group; Y?is a counter anion); R3is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; R4is a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, an alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted, E is a divalent aliphatic hydrocarbon group which may be substituted by group(s) other than oxo; G1is a bond, CO or SO2; G2is CO, SO2, NHCO, CONH or OCO; J is methine or a nitrogen atom; and each of Q and R is a bond or a divalent C1-3aliphatic hydrocarbon which may be substituted; provided that J is methine when G2is OCO, that one of Q and R is not a bond when the other is a bond and that each of Q and R is not substituted by oxo group(s) when G1is a bond) or a salt thereof has a potent CCR5 antagonistic activity and can be advantageously used for the treatment or prevention of infectious disease of various HIV in human (e.g. AIDS).