334013-94-4

Basic information

• Product Name: 2-(4-methoxy-3-((4-(trifluoromethoxy)benzamido)methyl)benzyl)butanoic acid
• Synonyms: 2-(4-methoxy-3-((4-(trifluoromethoxy)benzamido)methyl)benzyl)butanoic acid
• CAS NO: 334013-94-4
• Molecular Weight: 425.405
• Mol File: 334013-94-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxy-3-((4-(trifluoromethoxy)benzamido)methyl)benzyl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxy-3-((4-(trifluoromethoxy)benzamido)methyl)benzyl)butanoic acid(334013-94-4)
• EPA Substance Registry System: 2-(4-methoxy-3-((4-(trifluoromethoxy)benzamido)methyl)benzyl)butanoic acid(334013-94-4)

Safety Data

• Hazardous Substances Data: 334013-94-4(Hazardous Substances Data)

Upstream product

• 378232-24-7 ethyl 2-ethyl-3-[3-(hydroxyimino)-4-methoxyphenyl]propanoate 
• 378232-23-6 ethyl 2-ethyl-3-(3-formyl-4-methoxyphenyl)propanoate 
• 378232-17-8 ethyl 2-[1-(4-methoxyphenyl)methyl]butyrate 
• 123-11-5 4-methoxy-benzaldehyde 
• 53618-36-3 ethyl 2-ethyl-3-(4-methoxyphenyl)acrylate 
• 1310070-30-4 C₂₃H₂₆F₃NO₅ 

Relevant articles and documents

Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator- activated receptor (PPAR) α-selective agonists

A series of α-ethylphenylpropanoic acid derivatives was prepared as candidate peroxisome proliferator-activated receptor (PPAR) α-selective agonists, based on our PPARα/δ dual agonist 3 as a lead compound. Structure-activity relationship studies clearly indicated that the steric bulkiness and position of the distal hydrophobic tail part are critical for PPARα agonistic activity and PPARα selectivity, as had been predicted from a molecular-modeling study. A representative compound blocked the progression of nonalcoholic steatohepatitis (NASH) in an animal model.