378232-24-7Relevant academic research and scientific papers
Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator- activated receptor (PPAR) α-selective agonists
Ban, Shintaro,Kasuga, Jun-Ichi,Nakagome, Izumi,Nobusada, Hiromi,Takayama, Fusako,Hirono, Shuichi,Kawasaki, Hiromu,Hashimoto, Yuichi,Miyachi, Hiroyuki
, p. 3183 - 3191 (2011/06/24)
A series of α-ethylphenylpropanoic acid derivatives was prepared as candidate peroxisome proliferator-activated receptor (PPAR) α-selective agonists, based on our PPARα/δ dual agonist 3 as a lead compound. Structure-activity relationship studies clearly indicated that the steric bulkiness and position of the distal hydrophobic tail part are critical for PPARα agonistic activity and PPARα selectivity, as had been predicted from a molecular-modeling study. A representative compound blocked the progression of nonalcoholic steatohepatitis (NASH) in an animal model.
Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor α subtype-selective activators
Nomura, Masahiro,Tanase, Takahiro,Ide, Tomohiro,Tsunoda, Masaki,Suzuki, Masahiro,Uchiki, Hideharu,Murakami, Koji,Miyachi, Hiroyuki
, p. 3581 - 3599 (2007/10/03)
Substituted phenylpropanoic acid derivatives were prepared as part of a search for subtype-selective human peroxisome proliferator activated receptor α (PPARα) activators. Structure-activity relationship studies indicated that the nature and the stereoche
