334014-70-9Relevant academic research and scientific papers
Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor α subtype-selective activators
Nomura, Masahiro,Tanase, Takahiro,Ide, Tomohiro,Tsunoda, Masaki,Suzuki, Masahiro,Uchiki, Hideharu,Murakami, Koji,Miyachi, Hiroyuki
, p. 3581 - 3599 (2007/10/03)
Substituted phenylpropanoic acid derivatives were prepared as part of a search for subtype-selective human peroxisome proliferator activated receptor α (PPARα) activators. Structure-activity relationship studies indicated that the nature and the stereoche
Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: Novel human PPARα-selective activators
Miyachi, Hiroyuki,Nomura, Masahiro,Tanase, Takahiro,Takahashi, Yukie,Ide, Tomohiro,Tsunoda, Masaki,Murakami, Koji,Awano, Katsuya
, p. 77 - 80 (2007/10/03)
A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure-activity relationship studies indicated that the substituent at the α-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.
