33424-10-1

Upstream product

• 6954-50-3 1-isonicotinoyl-4-phenylthiosemicarbazide 
• 172661-61-9 C₁₉H₁₇N₅S 
• 172661-67-5 C₂₀H₁₉N₅S 
• 54-85-3 isoniazid 
• 103-72-0 phenyl isothiocyanate 
• 72140-25-1 N³-phenyl-4-picolinamidrazone 
• 1119010-84-2 2-cyanoethyl phenylcarbamodithioate 

Downstream Products

• 1262034-89-8 [Zn(phenyl-(5-pyridin-4-yl[1,3,4]thiadiazol-2-yl)-amine)2(CH₃COO)2(H₂O)2] 
• 1262034-88-7 [Co(phenyl-(5-pyridin-4-yl[1,3,4]thiadiazol-2-yl)-amine)(SO₄)(H₂O)4]*H₂O 

Relevant academic research and scientific papers

Studies on phenylmercury(II) complexes of nitrogen-sulfur ligands: Synthesis, spectral, structural characterization, TD-DFT and photoluminescent properties

The reactions of phenylmercury(II) acetate with N-phenyl-5-(pyridin-4-yl)- 1,3,4-thiadiazol-2-amine (Hppt) (1) and potassium N(4-methylpiperazine)-1- carbodithioate [K(mpcdt)] yielded [PhHg(ppt)] (2) and [PhHg(mpcdt)] (3). The complexes have been characte

Synthesis, characterization and antiamoebic activity of some hydrazone and azole derivatives bearing pyridyl moiety as a promising heterocyclic scaffold

In an effort to develop effective antiamoebic agents, some hydrazones and azoles containing pyridyl moiety were synthesized and screened for in vitro antiamoebic activity against HM1:IMSS strain of Entamoeba histolytica. Among all the compounds, only five compounds (1, 3, 5, 9 and 11) were found to be better inhibitors of growth of E. histolytica than the reference drug metronidazole. The cytotoxic studies of these compounds on human breast cancer MCF-7 cell line revealed that all the compounds were low-cytotoxic in the concentration range of 2.5-250 μM.

Dithiocarbamate as an efficient intermediate for the synthesis of 2-amino-1,3,4-thiadiazoles in water

A new and facile protocol for the synthesis of 2-amino-1,3,4-thiadiazoles in water is described. Reaction of acid hydrazides with easily prepared dithiocarbamates gives the corresponding thiadiazoles in moderate to excellent yields. 2-Amino-1,3,4-oxadiazoles were not observed as side products using this procedure.

Synthesis and anticonvulsant activity of substituted oxadiazole and thiadiazole derivatives

A series of five membered heterocyclics was synthesized by the reaction between isoniazid and various substituted isothiocyanates and was tested for their anticonvulsant activity by determining their ability to provide protection against convulsions induc

1,3,4-Thiadiazole derivatives. Synthesis, structure elucidation, and structure-antituberculosis activity relationship investigation

A series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized, the compounds structures were elucidated and screened for the antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system. Among the tested compounds, 2-phenylamino-5-(4-fluorophenyl) -1,3,4-thiadiazole 22 showed the highest inhibitory activity. The relationships between the structures of compounds and their antituberculosis activity were investigated by the Electronic-Topological Method (ETM) and feed forward neural networks (FFNNs) trained with the back-propagation algorithm. As a result of the approach, a system of pharmacophores and anti-pharmacophores has been found that effectively separates compounds of the examination set into groups of active and inactive compounds. The system can be applied to the screening and design of new active compounds possessing skeletons similar to those used in the present study.

THE REACTION OF N3-SUBSTITUTED OF 4-PICOLINE AMIDRAZONES WITH ISOTHIOCYANATES

In the reaction of N3-substituted of 4-picoline-amidrazones with isothiocyanates there were obtained the derivatives of thiosemicarbazone-4-picolinamides .The cyclization of these compounds at boiling temperature of glacial acetic acid led to formation of derivatives containing 1,3,4-thiadiazol system .Keywords: thiosemicarbazone-4-picolinamides derivatives, synthesis, elemental analysis, IR, 1H NMR.