334477-34-8

Basic information

• Product Name: C₁₅H₁₁F₆NO₂
• CAS NO: 334477-34-8
• Molecular Weight: 351.248
• Mol File: 334477-34-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₁F₆NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₁F₆NO₂(334477-34-8)
• EPA Substance Registry System: C₁₅H₁₁F₆NO₂(334477-34-8)

Safety Data

• Hazardous Substances Data: 334477-34-8(Hazardous Substances Data)

Upstream product

• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 26107-80-2 3’,5’-bis(trifluoromethyl)acetophenone 

Downstream Products

• 334477-35-9 3,4-dihydro-5-[3,5-bis(trifluoromethyl)phenyl]-2H-pyrrole 

Relevant articles and documents

Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK1 receptor antagonists

A focused exploration targeting conformationally restricted analogues of Vestipitant, resulted in the discovery of novel, in vitro potent NK1 antagonists. In particular, two of the compounds reported exhibited a good pharmacokinetic (PK) profile and produced anxiolytic-like effects in the gerbil foot tapping (GFT) in vivo model.