895521-36-5

Basic information

• Product Name: 2-Hydroxybutanedioic acid - (1R)-1-[3,5-bis(trifluoromethyl)phenyl]-N-methylethanamine (1:1)
• Synonyms: 2-Hydroxybutanedioic acid - (1R)-1-[3,5-bis(trifluoromethyl)phenyl]-N-methylethanamine (1:1)
• CAS NO: 895521-36-5
• Molecular Formula: C₄H₆O₅*C₁₁H₁₁F₆N
• Molecular Weight: 405.2895992
• Mol File: 895521-36-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 126-128°
• Appearance: /
• CAS DataBase Reference: 2-Hydroxybutanedioic acid - (1R)-1-[3,5-bis(trifluoromethyl)phenyl]-N-methylethanamine (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxybutanedioic acid - (1R)-1-[3,5-bis(trifluoromethyl)phenyl]-N-methylethanamine (1:1)(895521-36-5)
• EPA Substance Registry System: 2-Hydroxybutanedioic acid - (1R)-1-[3,5-bis(trifluoromethyl)phenyl]-N-methylethanamine (1:1)(895521-36-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 895521-36-5(Hazardous Substances Data)

Upstream product

• 617-48-1 malic acid 
• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 74-89-5 methylamine 

Downstream Products

• 1453070-40-0 (1S,8aS)-dimethyl 2-(methyl((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)carbamoyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-7,7(6H)-dicarboxylate 
• 1453068-21-7 (1S,8aS)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide 
• 1453068-22-8 (1R,8aR)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide 
• 1453068-67-1 N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide 
• 1453068-66-0 N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide 
• 1453068-71-7 N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-7-(hydroxymethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide 
• 1453068-70-6 N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-7-(hydroxymethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide 
• 1453068-68-2 N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-7-(hydroxymethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide 
• 1453068-69-3 N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-7-(hydroxymethyl)-N-methyl-1-(2-methylphenyl)-6-oxo-octahydropyrrolo[1,2-a]piperazine-2-carboxamide 
• 1453068-73-9 N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)octahydropyrrolo[1,2-a]piperazine-2-carboxamide 
• 1453068-72-8 N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7,7-bis(2-hydroxyethyl)-N-methyl-1-(2-methylphenyl)octahydropyrrolo[1,2-a]piperazine-2-carboxamide 
• 1453068-77-3 N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-N-methyl-1-(2-methylphenyl)octahydropyrrolo[1,2-a]piperazine-2-carboxamide 
• 1453068-76-2 N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-N-methyl-1-(2-methylphenyl)octahydropyrrolo[1,2-a]piperazine-2-carboxamide 
• 1453068-81-9 N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-7-(hydroxymethyl)-N-methyl-1-(2-methylphenyl)octahydropyrrolo[1,2-a]piperazine-2-carboxamide 

Relevant articles and documents

NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS

The present invention relates to a compound according to formula (A) wherein n is 1 or 2; R1 and R2 are independently hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, CD3 or halogen; R3 is hydrogen, C(=O)OR7 or C1-4 alkyl optionally substituted with hyd