33468-85-8

Basic information

• Product Name: 2-(2-Pyridyl)-4-trifluoromethylimidazole
• Synonyms: 2-(4-(trifluoromethyl)-1H-imidazol-2-yl)pyridine;2-(2-PYRIDYL)-4-TRIFLUOROMETHYLIMIDAZOLE;2-Pyridin-2-yl-4-(trifluoromethyl)-1H-imidazole
• CAS NO: 33468-85-8
• Molecular Formula: C9H6F3N3
• Molecular Weight: 213.16
• Product Categories: Heterocycle
• Mol File: 33468-85-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 160-161 °C
• Boiling Point: 369.3 °C at 760 mmHg
• Flash Point: 177.2 °C
• Appearance: /
• Density: 1.393
• Vapor Pressure: 2.54E-05mmHg at 25°C
• Refractive Index: 1.519
• CAS DataBase Reference: 2-(2-Pyridyl)-4-trifluoromethylimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Pyridyl)-4-trifluoromethylimidazole(33468-85-8)
• EPA Substance Registry System: 2-(2-Pyridyl)-4-trifluoromethylimidazole(33468-85-8)

Safety Data

• Hazardous Substances Data: 33468-85-8(Hazardous Substances Data)

Usage

General Description

2-(2-Pyridyl)-4-trifluoromethylimidazole, also known as PTI, is a chemical compound with the molecular formula C9H6F3N3. It is a member of the imidazole family and is characterized by a pyridyl group attached to the second carbon of the imidazole ring. PTI is often used as a ligand in the coordination chemistry of transition metals and has been studied for its potential applications in catalysis, pharmaceuticals, and materials science. Its trifluoromethyl group also makes it a valuable building block in organic synthesis. PTI is a highly versatile and valuable chemical compound with a wide range of potential uses in various scientific and industrial fields.

InChI:InChI=1/C9H6F3N3/c10-9(11,12)7-5-14-8(15-7)6-3-1-2-4-13-6/h1-5H,(H,14,15)

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 431-67-4 1,1-dibromo-3,3,3-trifluoroacetone 

Downstream Products

• 279251-08-0 2-(2-pyridyl)-1H-4-imidazolcarbaldehyde 
• 279250-91-8 2-(2-pyridyl)-4-cyano-1H-imidazole 

Relevant articles and documents

THERAPEUTIC COMPOUNDS AND USES THEREOF

The present invention relates to compounds formula (I): and to salts thereof, wherein R1-R4 and A have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of histone demethylases, such as KDM5. Also included are pharmaceutically acceptable compositions comprising the compounds of the present invention and methods of using said compositions in the treatment of various disorders.

Trifluoromethylimidazoles and a method for their preparation

4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammoni

4-Trifluoromethylimidazoles and 5-(4-pyridyl)-1,2,4-triazoles, new classes of xanthine oxidase inhibitors.

The syntheses of a number of 2-substituted 4-trifluoromethylimidazoles and 3-substituted 5-(4-pyridyl)-1,2,4-triazoles are described. The trifluoromethylimidazoles were prepared from 3,3-dibromo-1,1,1-trifluoroacetone after hydrolysis with aqueous sodium acetate solution and condensation with an aldehyde in the presence of ammonia. Basic hydrolysis of the trifluoromethyl group was found to provide a facile method for the synthesis of imidazole-4-carboxylic acids. In the imidazole series a 2-aryl substituent and a free imino group were required for xanthine oxidase inhibitory activity. The triazoles were obtained through the reaction of an aroylhydrazine and an imino ether followed by thermal ring closure of the intermediate acylamidrazone. As in the imidazole series, a free imino group is an absolute requirement for in vitro activity. Additional structure-activity relationships of these compounds are presented.