334686-37-2

Upstream product

• 2441-46-5 1,2,4,5-tetramethoxybenzene 
• 334686-33-8 2-(2,3,5,6-tetramethoxyphenyl)ethan-1-ol 
• 334686-34-9 2-(2,3,5,6-tetramethoxyphenyl)ethanal 
• 334686-36-1 ethyl (E)-2-methyl-4-(2,3,5,6-tetramethoxyphenyl)-2-butenoate 

Downstream Products

• 114466-78-3 (-)-metachromin A methyl ether 
• 114466-74-9 Metachromin A 
• 334686-27-0 3-[(E)-4-bromo-3-methyl-2-butenyl]-1,2,4,5-tetramethoxybenzene 
• 334686-39-4 (-)-3-{(E)-5-[(1R,3R)-1,3-dimethyl-2-methylenecyclohexyl]-3-methyl-2-pentenyl}-1,2,4,5-tetramethoxybenzene 
• 334686-51-0 (+)-3-{(E)-5-[(1S,3S)-1,3-dimethyl-2-methylenecyclohexyl]-3-methyl-2-pentenyl}-1,2,4,5-tetramethoxybenzene 
• 334686-50-9 (-)-2-[(1R,3S)-1,3-dimethyl-2-methylenecyclohexyl]-2-[(E)-2-methyl-4-(2,3,5,6-tetramethoxyphenyl)-2-butenyl]-1,3-dithiane 
• 334686-38-3 (+)-2-[(1S,3R)-1,3-dimethyl-2-methylenecyclohexyl]-2-[(E)-2-methyl-4-(2,3,5,6-tetramethoxyphenyl)-2-butenyl]-1,3-dithiane 

Relevant academic research and scientific papers

First enantioselective total synthesis of both (+)- and (-)-metachromin A

The antineoplastic agent (-)-metachromin A (1) from Hippospongia metachromia has been synthesized in enantiomerically pure form in 13% overall yield. A general convergent synthetic strategy for different metachromins using a 2-alkyloxy-3-sulfonyl-l,3-oxazolidine as a chiral dithienium equivalent is presented.