334686-50-9

Upstream product

• 334686-40-7 (+)-2-[(1R,3S)-1,3-dimethyl-2-methylenecyclohexyl]-1,3-dithiane 
• 334686-27-0 3-[(E)-4-bromo-3-methyl-2-butenyl]-1,2,4,5-tetramethoxybenzene 
• 2441-46-5 1,2,4,5-tetramethoxybenzene 
• 334686-34-9 2-(2,3,5,6-tetramethoxyphenyl)ethanal 
• 334686-33-8 2-(2,3,5,6-tetramethoxyphenyl)ethan-1-ol 
• 334686-37-2 (E)-2-methyl-4-(2,3,5,6-tetramethoxyphenyl)-2-buten-1-ol 
• 334686-36-1 ethyl (E)-2-methyl-4-(2,3,5,6-tetramethoxyphenyl)-2-butenoate 
• 334686-41-8 (+)-(2S)-2-{(2R,4R)-4-ethyl-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidin-2-yl}-2-methylcyclohexan-1-one 
• 334686-48-5 (-)-(2S,6S)-2-{(2R,4R)-4-ethyl-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidin-2-yl}-2,6-dimethylcyclohexan-1-one 
• 334686-46-3 (+)-(2R,4R)-2-[(1R,3S)-1,3-dimethyl-2-methylenecyclohexyl]-4-ethyl-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidine 

Downstream Products

• 334686-51-0 (+)-3-{(E)-5-[(1S,3S)-1,3-dimethyl-2-methylenecyclohexyl]-3-methyl-2-pentenyl}-1,2,4,5-tetramethoxybenzene 

Relevant academic research and scientific papers

First enantioselective total synthesis of both (+)- and (-)-metachromin A

The antineoplastic agent (-)-metachromin A (1) from Hippospongia metachromia has been synthesized in enantiomerically pure form in 13% overall yield. A general convergent synthetic strategy for different metachromins using a 2-alkyloxy-3-sulfonyl-l,3-oxazolidine as a chiral dithienium equivalent is presented.