33471-99-7Relevant academic research and scientific papers
Inhibition of mandelate racemase by the substrate-intermediate-product analogue 1,1-diphenyl-1-hydroxymethylphosphonate
Burley, Rodney K. M.,Bearne, Stephen L.
, p. 4342 - 4344 (2005)
Mandelate racemase has been studied as a paradigm for enzyme-catalyzed abstraction of a proton from carbon acids with relatively high pKa values. 1,1-Diphenyl-1-hydroxymethylphosphonate is a substrate-intermediate- product analogue and is a mod
Nucleophilic fluorination of α-aroylphosphinates with morpholinosulfur trifluoride
Zasukha, Sergiy V.,Guzyr, Olexandr I.,Shermolovich, Yuriy G.
, p. 256 - 264 (2014/07/22)
Nucleophilic fluorination of aroyl-phenyl-phosphinates is highly dependent on the nature of the alkoxy substituents attached to the phosphoryl group. A reaction of aroyl-phenyl-phosphinates with morpholinosulfur trifluoride was shown to be a convenient synthetic method for high-yield synthesis of α,α-difluorobenzyl-phenyl-phosphinates using steric protection of the phosphoryl group by a bulky isopropoxy substituent. The methyl esters of aroylphosphinic acids in the same reaction conditions yield (fluoro-diaryl- methyl)-pentafluorophosphates as the main reaction products.
