33477-30-4

Upstream product

• 21691-57-6 L-leucine p-nitrobenzyl ester 
• 80645-36-9 Boc-Phe-ONp-Pic 
• 75243-95-7 3-O--hydroxy-2-phenylindenone 
• 7413-59-4 hydrochloride of p-nitrobenzyl ester of L-Leucine 
• 81638-94-0 O-(t-butyloxycarbonyl-L-phenylalanyl)-2-pyridylmethylketoxime 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 75244-02-9 4-nitrobenzyl ester of L-phenylalanyl-L-leucine hydrochloride 
• 58822-25-6 Leu-enkephalin 
• 75244-06-3 4-nitrobenzyl ester of N-t-butyloxycarbonylglycylglycyl-L-phenylalanyl-L-leucine 
• 81649-51-6 hydrochloride of 4-nitrobenzyl ester of glycyl-glycyl-L-phenylalanyl-L-leucine 
• 75244-08-5 4-nitrobenzyl ester of N-benzyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine 
• 75244-07-4 glycylglycyl-L-phenylalanyl-L-leucine p-nitrobenzyl ester hydrobromide 

Relevant academic research and scientific papers

Protected Amino Acid Active Esters Incorporating the 4-Picolyl Basic Solubilizing Group

The 4-picolyl ester of 4-hydroxy-3-nitrophenylacetic acid has been prepared from an active polyester intermediate, and used as the precursor of a series of protected amino acid active esters.These compounds were satifactory coupling components in peptide syntheses.Purification of the protected peptides by acid washing was facilitated by the presence of the basic 4-picolyl moiety.

O-(N-ACYLAMINOACYL)-2-PYRIDYLMETHYLKETOXIMES AND THEIR USE IN PEPTIDE SYNTHESIS

Preparation of Leu-enkephalin, Met-enkephalin and one analog of Leu-enkephalin by using O-(N-acylaminoacyl)-2-pyridylketoximes is described.Both the side products and the unreacted active amino acid derivatives were removed by utilizing the formation of a copper complex with 2-pyridylmethylketoxime.

3-O--HYDROXY-2-PHENYLINDENONES, PREPARATION AND USE IN THE SYNTHESIS OF PEPTIDES

Several 3-O--hydroxy-2-phenylindenones were obtained and used in the synthesis of peptides.Synthesis of Leu-enkephalin was carried out.