75244-06-3

Upstream product

• 39621-73-3 N-t-butyloxycarbonylglycylglycyl-L-phenylalanine 
• 7413-59-4 hydrochloride of p-nitrobenzyl ester of L-Leucine 
• 75243-92-4 3-O--hydroxy-2-phenylindenone 
• 75244-02-9 4-nitrobenzyl ester of L-phenylalanyl-L-leucine hydrochloride 
• 81638-93-9 O-(N-t-butyloxycarbonylglycylglycyl)-2-pyridylmethylketoxime 
• 31972-52-8 Boc-Gly-Gly-OH 
• 63631-32-3 (S)-methyl 12-benzyl-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate 
• 33477-30-4 4-nitrobenzyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-leucine 
• 75243-95-7 3-O--hydroxy-2-phenylindenone 
• 81638-94-0 O-(t-butyloxycarbonyl-L-phenylalanyl)-2-pyridylmethylketoxime 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 81649-51-6 hydrochloride of 4-nitrobenzyl ester of glycyl-glycyl-L-phenylalanyl-L-leucine 
• 75244-07-4 glycylglycyl-L-phenylalanyl-L-leucine p-nitrobenzyl ester hydrobromide 
• 58822-25-6 Leu-enkephalin 
• 75244-08-5 4-nitrobenzyl ester of N-benzyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine 

Relevant academic research and scientific papers

INFLUENCE OF ADDITIVES ON SUPPRESSION OF RACEMIZATION IN PEPTIDE SYNTHESIS. PART IV. THE USE OF ADDITIVES FOR SUPPRESSION OF RACEMIZATION IN PEPTIDE SYNTHESIS BY THE METHOD OF MIXED ANHYDRIDES

The changes of employing antiracemization additives in peptide synthesis by the method of mixed anhydrides were investigated by the Anderson and NMR tests.

Additives Based on Liquid Crystal Forming Structure Elements for Suppressing Racemization in Peptide Synthesis by the DCC- and Mixed Anhydrides Methods

A new type of additives suppressing racemization during peptide synthesis by the DCC- and mixed anhydrides methods are liquid crystal forming organic molecules or similar compounds with a specific long chain structure.The suppressing effect of the new additives was followed by the Anderson test, the modifid Young and n.m.r. tests.There was no racemization in a new Leu-enkephalin synthesis by the mixed anhydrides method with azoxybenzene as additive.

O-(N-ACYLAMINOACYL)-2-PYRIDYLMETHYLKETOXIMES AND THEIR USE IN PEPTIDE SYNTHESIS

Preparation of Leu-enkephalin, Met-enkephalin and one analog of Leu-enkephalin by using O-(N-acylaminoacyl)-2-pyridylketoximes is described.Both the side products and the unreacted active amino acid derivatives were removed by utilizing the formation of a copper complex with 2-pyridylmethylketoxime.

3-O--HYDROXY-2-PHENYLINDENONES, PREPARATION AND USE IN THE SYNTHESIS OF PEPTIDES

Several 3-O--hydroxy-2-phenylindenones were obtained and used in the synthesis of peptides.Synthesis of Leu-enkephalin was carried out.