33486-88-3Relevant academic research and scientific papers
Alkyne metathesis: Development of a novel molybdenum-based catalyst system and its application to the total synthesis of epothilone A and C
Fuerstner, Alois,Mathes, Christian,Lehmann, Christian W.
, p. 5299 - 5317 (2007/10/03)
Sterically hindered molybdenum(III) amido complexes of the general type [Mo{(tBu)(Ar)N}3] (1), upon treatment with CH2Cl2 or other halogen donors, have been converted into highly effective catalysts for all kinds of alkyne metathesis reactions. Although the actual nature of the propagating species formed in situ is still elusive, halogen transfer to the Mo center of 1 plays a decisive role in the activation of such precatalysts. It was possible to isolate and characterize by X-ray crystallography some of the resulting molybdenum halide derivatives such as 15, 16 and 20 which themselves were shown to be catalytically active. Numerous applications illustrate the performance of the catalytic system 1/CH2Cl2 which operates under mild conditions and tolerates an array of polar functional groups. The wide scope allows the method to be implemented into the total synthesis of sensitive and polyfunctional natural products. Most notable among them is a concise entry into the potent anticancer agents epothilone A (86) and C (88). The macrolide core of these targets is forged by ring closing alkyne metathesis (RCAM) of diyne 113, followed by Lindlar hydrogenation of cycloalkyne 114 thus formed. Since this strategy opens a stereoselective entry into (Z)-alkene 115, the approach is inherently more efficient than previous syntheses based on conventional RCM. Wiley-VCH Verlag GmbH, 2001.
Exited State Substitution and Addition Reactions of Aryl Fluorides with Aliphatic Amines
Gilbert, Andrew,Krestonosich, Stefan
, p. 1393 - 1399 (2007/10/02)
Fluorobenzene and the difluorobenzenes undergo photochemical reaction with t-butylamine and diethylamine to give both 1:1 adducts and substitution products but only the latter are formed from hexafluorobenzene and diethylamine.Both cine and 'normal' substitution products are observed from the difluoro-compounds and the mechanism to account for this is considered to involve a polar excited-state complex between the addends and an addition-elimination process rather than benzyne intermediates. 1,2-Acyclic amine photoadducts are produced from most systems but the corresponding 1,4-isomers are the major adducts from p-difluorobenzene and that from diethylamine is unique in undergoing thermal retro-addition to the starting materials rather than conversion into the aniline derivative.
