33498-87-2

Upstream product

• 99776-33-7 (((2-(2,2-dimethoxyethyl)propane-1,3-diyl)bis(oxy))bis(methylene))dibenzene 
• 1093350-25-4 3,3-bis (benzyloxymethyl)acrylonitrile 
• 1093350-26-5 3,3-bis(benzyloxymethyl)propionitrile 
• 24156-71-6 2-(2,2-dimethoxyethyl)malonic acid diethyl ester 
• 33498-88-3 4-(benzyloxy)-3-((benzyloxy)methyl)butan-1-ol 
• 1556859-28-9 (((2-(2-azidoethyl)propane-1,3-diyl)bis(oxy))bis(methylene))dibenzene 
• 99776-32-6 2-(hydroxymethyl)-4,4-dimethoxybutan-1-ol 
• 99776-34-8 4-benzyloxy-3-benzyloxymethylbutyraldehyde 

Downstream Products

• 1026287-77-3 N⁴-(4-Benzyloxy-3-benzyloxymethyl-butyl)-6-chloro-pyrimidine-2,4-diamine 
• 1026811-37-9 N⁴-(4-Benzyloxy-3-benzyloxymethyl-butyl)-6-chloro-pyrimidine-2,4,5-triamine 
• 1028315-22-1 2-Amino-9-(4-benzyloxy-3-benzyloxymethyl-butyl)-6-chloro-7,9-dihydro-purin-8-one 
• 1026175-16-5 7-Allyl-2-amino-9-(4-benzyloxy-3-benzyloxymethyl-butyl)-6-chloro-7,9-dihydro-purin-8-one 
• 1564251-47-3 (S)-2-acetamido-N⁴-(4-(benzyloxy)-3-((benzyloxy)methyl)butyl)-N¹-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)succinamide 
• 1564251-50-8 (S)-2-acetamido-N⁵-(4-(benzyloxy)-3-((benzyloxy)methyl)butyl)-N¹-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)pentanediamide 
• 1564251-65-5 C₄₃H₆₄BN₃O₈ 
• 1610774-90-7 C₃₅H₄₄N₂O₇ 

Relevant academic research and scientific papers

Rational hopping of a peptidic scaffold into non-peptidic scaffolds: Structurally novel potent proteasome inhibitors derived from a natural product, belactosin A

Rational scaffold hopping of a natural product belactosin A derivative was successfully achieved based on the pharmacophore model constructed. The peptidic scaffold was replaced by significantly simplified non-peptidic scaffolds, by which weak belactosin A (IC50 = 1440 nM) was converted into highly potent non-peptidic inhibitors (IC50 = 26-393 nM).

PROCESS FOR PREPARING PURINE DERIVATIVE

A process for the preparation of famciclovir a compound of Formula (I) and its intermediates.

AN IMPROVED PROCESS FOR PREPARING PURINE DERIVATIVE

A process for the preparation of famciclovir a compound of Formula (I) and its intermediates.