33498-88-3

Upstream product

• 99776-34-8 4-benzyloxy-3-benzyloxymethylbutyraldehyde 
• 99776-32-6 2-(hydroxymethyl)-4,4-dimethoxybutan-1-ol 
• 99776-33-7 (((2-(2,2-dimethoxyethyl)propane-1,3-diyl)bis(oxy))bis(methylene))dibenzene 
• 24156-71-6 2-(2,2-dimethoxyethyl)malonic acid diethyl ester 

Downstream Products

• 1556859-28-9 (((2-(2-azidoethyl)propane-1,3-diyl)bis(oxy))bis(methylene))dibenzene 
• 33498-87-2 4-(benzyloxy)-3-((benzyloxy)methyl)butan-1-amine 
• 1556859-32-5 5-(benzyloxy)-4-((benzyloxy)methyl)pentanenitrile 
• 1556858-78-6 C₂₇H₃₅NO₅ 
• 1564251-64-4 C₂₀H₂₇NO₂ 
• 1556858-85-5 C₂₈H₃₇NO₅ 

Relevant academic research and scientific papers

Rational hopping of a peptidic scaffold into non-peptidic scaffolds: Structurally novel potent proteasome inhibitors derived from a natural product, belactosin A

Rational scaffold hopping of a natural product belactosin A derivative was successfully achieved based on the pharmacophore model constructed. The peptidic scaffold was replaced by significantly simplified non-peptidic scaffolds, by which weak belactosin A (IC50 = 1440 nM) was converted into highly potent non-peptidic inhibitors (IC50 = 26-393 nM).

GUANINE DERIVATIVE

Antivirally active compounds of the formula STR1 wherein A is STR2 wherein m is 1 or 2, n is 1 or 2, whereby m is 1 when n is 2 and m is 2 when n is 1, R a ' is (CH 2) p OH, NHCONH 2 or COR a ", R a " is hydrogen, hydroxy or amino, p is 1 to 4, R b ' and R b " are independently selected from hydrogen or (CH 2) p OH, with the proviso that at least one of R b ' or R b " is hydrogen; or R b ' and R b " together constitute an additional carbon-carbon bond to form an alkyne; or a physiologically acceptable salt, geometric or optical isomer thereof; pharmaceutical preparations containing the compounds and methods for treatment of virus infections.