335159-82-5

Basic information

• Product Name: Benzenepropanoyl chloride, 3-broMo-
• Synonyms: Benzenepropanoyl chloride, 3-broMo-
• CAS NO: 335159-82-5
• Molecular Formula: C₉H₈BrClO
• Molecular Weight: 247.51622
• Mol File: 335159-82-5.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenepropanoyl chloride, 3-broMo-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoyl chloride, 3-broMo-(335159-82-5)
• EPA Substance Registry System: Benzenepropanoyl chloride, 3-broMo-(335159-82-5)

Safety Data

• Hazardous Substances Data: 335159-82-5(Hazardous Substances Data)

Upstream product

• 15115-58-9 3-(2-bromophenyl)propionic acid 
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• 125115-01-7 m-bromobenzylmalonic acid 
• 107558-73-6 diethyl 2-(3-bromobenzyl)-malonate 
• 15852-73-0 (3-Bromophenyl)methanol 
• 42287-90-1 3-(3-bromophenyl)propanoic acid 

Downstream Products

• 3279-90-1 6-bromo-3,4-dihydro-1H-quinolin-2-one 
• 1228680-89-4 3-Bromobenzyl-acetohydroxamic acid 
• 1098103-80-0 1-(3-(3-aminopropyl)phenyl)-3-ethylpent-1-yn-3-ol 
• 1514926-80-7 3-(3-bromophenyl)-N-(8-quinolinyl)propanamide 
• 1378311-80-8 3-(3-bromophenyl)-N-cyclopropylpropanamide 
• 1595289-93-2 3-(3-(4-(1H-indazol-5-ylamino)pyrimidin-2-yl)phenyl)-N-cyclopropylpropanamide 
• 1595291-45-4 tert-butyl 5-(tert-butoxycarbonyl(2-(3-(3-(cyclopropylamino)-3-oxopropyl)phenyl)pyrimidin-4-yl)amino)-1H-indazole-1-carboxylate 
• 1595291-44-3 N-cyclopropyl-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanamide 
• 78383-17-2 4-phenylindan-1-one 
• 16657-10-6 (±)-4-bromo-2,3-dihydro-1H-inden-1-ol 
• 615534-55-9 3-(3-bromophenyl)propionamide 
• 1190732-28-5 N-(4,4-diethoxybutyl)-3-(3-bromo-phenyl)propionamide 
• 25724-79-2 5-cyano-1-indanone 

Relevant articles and documents

Ruthenium-catalyzed intramolecular arene C(sp2)-H amidation for synthesis of 3,4-dihydroquinolin-2(1 H)-ones

We report the [Ru(p-cymene)(l-proline)Cl] ([Ru1])-catalyzed cyclization of 1,4,2-dioxazol-5-ones to form dihydroquinoline-2-ones in excellent yields with excellent regioselectivity via a formal intramolecular arene C(sp2)-H amidation. The reactions of the 2- and 4-substituted aryl dioxazolones proceeds initially through spirolactamization via electrophilic amidation at the arene site, which is para or ortho to the substituent. A Hammett correlation study showed that the spirolactamization is likely to occur by electrophilic nitrenoid attack at the arene, which is characterized by a negative ρ value of -0.73.

Ligand-Assisted Palladium(II)/(IV) Oxidation for sp3C H Fluorination

The direct functionalization of inert sp3C H bonds is limited to a few bond types. Although the activation of sp3C H bonds can be accomplished under mild conditions using palladium catalysts, the subsequent functionalization is not trivial due to the high energy required to convert palladium(II) to palladium(IV). We have systematically studied the palladium oxidation using computation-guided experiments for reactions involving strong chelation control. We find that a mild external ligand could significantly accelerate the oxidation of palladium(II) to palladium(IV) for strong bidentate directing groups. The acceleration is believed to be a result of ligand stabilization of both the palladium(II) and palladium(IV) intermediates. (Figure presented.) .

Synthesis of Alkyl-Substituted Pyridines by Directed Pd(II)-Catalyzed C-H Activation of Alkanoic Amides

A general alkylation protocol for substituted iodopyridines was developed (32 examples, 44-97% yield). The reaction is based on the Pd(II)-catalyzed C-H activation of 8-aminoquinoline-derived alkanoic amides and it employs a catalyst cocktail of Pd(OAc)2 (10 mol%), NaI (30 mol%), and (BuO)2POOH (20 mol%), with Ag2CO3 as base.