78383-17-2

Usage

Uses

Used in Pharmaceutical Industry:
4-phenyl-2,3-dihydro-1H-inden-1-one is used as a key intermediate in the synthesis of various pharmaceutical compounds due to its unique structure and reactivity. It plays a crucial role in the development of new drugs and biologically active molecules.
Used in Agriculture:
4-phenyl-2,3-dihydro-1H-inden-1-one is used as an antimicrobial agent in agriculture to protect crops from various diseases and pests. Its antimicrobial properties help in controlling the growth of harmful microorganisms and ensuring better crop yield.
Used in Material Science:
4-phenyl-2,3-dihydro-1H-inden-1-one is used as a building block in the development of new materials with specific properties. Its unique structure and reactivity make it suitable for creating materials with improved characteristics, such as enhanced stability, durability, and performance.
Used in Antioxidant Applications:
4-phenyl-2,3-dihydro-1H-inden-1-one is used as an antioxidant in various industries, including food, cosmetics, and pharmaceuticals. Its antioxidant properties help in preventing the oxidation of sensitive compounds, thereby extending their shelf life and maintaining their quality.

Upstream product

• 15115-60-3 4-bromo-2,3-dihydroinden-1-one 
• 98-80-6 phenylboronic acid 
• 42287-90-1 3-(3-bromophenyl)propanoic acid 
• 335159-82-5 3-(m-bromophenyl)propionyl chloride 
• 75-15-0 carbon disulfide 
• 7719-09-7 thionyl chloride 
• 19853-17-9 3-(biphenyl-2-yl)propanoic acid 

Downstream Products

• 78383-19-4 7-phenylindene 

Relevant academic research and scientific papers

Enantioselective Synthesis of Chiral Indane Derivatives by Rhodium-Catalyzed Addition of Arylboron Reagents to Substituted Indenes

Rhodium-catalyzed asymmetric addition of arylboron reagents to indene derivatives proceeded to give 2-arylindanes in good yields with high enantioselectivity. Deuterium-labeling experiments indicated that the present reaction involved a 1,4-Rh shift from an initially formed benzylrhodium to an arylrhodium intermediate before protonation leading to the corresponding addition product. The asymmetric addition was also successful for acenaphthylene, which has a similar skeleton to indene, where it was found that the benzylrhodium intermediate underwent direct protonation without the 1,4-Rh shift.

Ring-fused compound, preparation method thereof and application of compound

The invention relates to a ring-fused compound or pharmaceutically acceptable salt thereof, ester, a steric isomer, a tautomer, a polymorphic substance, a solvate, a hydrate, a metabolite or prodrug or mixture of the materials, a medicine composition and medicine box product comprising the compound, a preparation method of the compound and an application of the compound to preparation of medicinesfor preventing or treating PD-1/PD-L1 related diseases.

IMMUNOMODULATOR COMPOUNDS

Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Copper-Catalyzed Enantioselective Domino Arylation/Semipinacol Rearrangement of Allylic Alcohols with Diaryliodonium Salts

A copper-catalyzed enantioselective arylative semipinacol rearrangement of allylic alcohols was developed. In the presence of a catalytic amount of an in situ generated chiral copper-bisoxazoline complex, reaction of allylic alcohols with diaryliodonium salts afforded spirocycloalkanones in high yields with high diastereo- and enantioselectivities. A two-point binding model engaging the carbon–carbon double bond and the proximal hydroxyl group was proposed to be responsible for the highly efficient chirality transfer.

INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS

The present invention relates to new indene derivatives having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.

Indene derivatives, their preparation and use as medicaments

The present invention relates to new indene derivatives having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.

THERAPEUTIC AGENTS

The invention provides well-defined compounds that are either EP2 agonists, EP4 agonists, or mixed EP2/EP4 agonist. The compounds are useful for treating a variety of pathological conditions associated with acti

Palladium nanoparticles in Suzuki cross-couplings: Tapping into the potential of tris-imidazolium salts for nanoparticle stabilization

Inspired by the proclivity of various palladium sources to form nanoparticles in imidazolium-based ionic liquids, we now report that tris-imidazolium salts bearing hexadecyl chains and a bridging mesitylene moiety are potent stabilizers of palladium nanoparticles efficiently prepared via a Chaudret-type hydrogenation of the bis(dibenzylideneacetone)palladium(0). The palladium nanoparticles have been isolated in pure form and characterized by 1H nuclear magnetic resonance, transmission electron microscopy, electron diffraction and dynamic light scattering. The new materials proved effective in Suzuki cross-coupling at a loading of 0.2% palladium. Thus, using a tris-imidazolium iodide-palladium material, a series of biaryl products has been prepared starting from aryl bromides and some activated chlorides. The possibility that this catalytic activity might be due to the formation of palladium N-heterocyclic carbenes has been addressed through solid state 13C NMR and the synthesis of an imidazolium analogue in which the acidic 2-H was replaced with a methyl group. Copyright

4-Phenyl-2-indanyl esters of 1R,cis-3-(2-halo-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylic acid

Insecticidal 4-phenyl-2-indanyl 1R,cis-3-(2-halo-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylates having a racemic or optically active indanyl moiety, methods of preparation and use, and efficacy data against representative insect species are disclosed and exemplified.

Insecticidal pyrethroid enantiomer pair

An insecticidal enantiomer pair consisting essentially of a substantially equimolar mixture of S-4-phenyl-2-indanyl 1R, cis-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate and R-4-phenyl-2-indanyl 1S,cis-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate, its preparation by liquid chromatography, and its utility as an insecticide are described and exemplified.