335318-13-3

Upstream product

• 75-44-5 phosgene 
• 335318-29-1 4-amino-2-benzylsulfanyl-pyrimidine-5-carboxylate 
• 335318-30-4 5-(2-chlorophenyl)aminomethyl-4-amino-2-benzylthiopyrimidine 
• 6192-52-5 p-toluenesulfonic acid monohydrate 
• 95-51-2 o-chloroaniline 

Downstream Products

• 335318-20-2 7-benzylthio-3-(2-chlorophenyl)-1-(ethoxycarbonylmethyl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one 

Relevant academic research and scientific papers

Alkylamino-substituted bicyclic nitrogen heterocycles

Alkylamino-substituted dihydropyrimido[4,5-d]pyrimidinone derivatives are provided which are useful as inhibitors of p38, along with a process for their manufacture and pharmaceutical preparations containing them.

Heteroalkylamino-substituted bicyclic nitrogen heterocycles

The invention provides compounds represented by the formula: wherein R1, R2, R3, R4, and n are as defined in the Summary of the Invention; and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.