335349-80-9

Upstream product

• 123-90-0 Thiomorpholin 
• 335349-60-5 (5-chloro-4-iodo-2-nitro-phenyl)-carbamic acid tert-butyl ester 

Downstream Products

• 335350-64-6 (2-amino-4-iodo-5-thiomorpholin-4-yl-phenyl)-carbamic acid tert.-butyl ester 

Relevant academic research and scientific papers

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1

A series of 1,3-dihydrobenzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Attachment of an 8-(2-aryl)-ethynyl-moiety produced compounds inhibiting the binding of [3H]-LY354740 to rat mGluR2 with low n

Glutamate receptor antagonists

The present invention relates to compounds of with a base structure of formula 1 The compounds of formula I are shown to have activity as metabotropic glutamate receptor antagonists.