33538-88-4

Usage

InChI:InChI=1/C11H14O3/c1-13-10-5-6-11(14-2)9(8-10)4-3-7-12/h5-8H,3-4H2,1-2H3

Upstream product

• 102882-06-4 2-(2,5-dimethoxy-phenethyl)-[1,3]dioxolane 
• 100126-94-1 3-(2,5-dimethoxyphenyl)propionyl chloride 
• 117646-10-3 5-(2',5'-dimethoxybenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 33538-76-0 5-Methoxy-2-hydroxyhydrozimtalkohol 
• 20920-98-3 6-methoxy-3,4-dihydrocoumarin 
• 1201-38-3 2',5'-dimethoxyacetophenone 
• 108950-30-7 1-(2,5-dimethoxy-phenyl)-2-[1,3]dioxolan-2-yl-ethanone 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 33538-81-7 3-(2,5-Dimethoxyphenyl)propanol 

Downstream Products

• 129150-10-3 1-<4,4-(1,2-Benzenediyldithio)but-3-enyl>-2,5-dimethoxybenzene 
• 828271-79-0 2-(2,5-dimethoxybenzyl)acrylaldehyde 

Relevant academic research and scientific papers

Tandem molybdenum catalyzed hydrosilylations: An expedient synthesis of β-aryl aldehydes

The synthesis of β-aryl aldehydes utilizing a tandem molybdenum catalyzed hydrosilylation is described. This new functional group interconversion provides an efficient method for the two-carbon homologation of aryl aldehydes.

Structural variations of piritrexim, a lipophilic inhibitor of human dihydrofolate reductase: Synthesis, antitumor activity and molecular modeling investigations

Piritrexim (PTX) (1), a lipophilic inhibitor of the human dihydrofolate reductase, has been evaluated as an anticancer agent. The synthesis of four structural variations (2-5) of PTX is reported. The PTX analogues 2-5 were obtained by reaction of suitable C3-building blocks with pyrimidine-2,4,6-triamine (14) or with cyanacetamide (7) and guanidine (10). The evaluation of 2-4 for antitumor activity against a panel of 60 human cancer cell lines showed inhibitory effects on the growth of the cell lines. These data are supported by molecular modeling and docking studies, which show that compounds 2-4 share the same binding mode within the DHFR active site. Moreover, the estimated ligand binding energies are in good agreement with the experimental activity data.