117646-10-3Relevant academic research and scientific papers
A transition metal free expedient approach for the C[dbnd]C bond cleavage of arylidene Meldrum's acid and malononitrile derivatives
Suresh, Muthiah,Kumari, Anusueya,Singh, Raj Bahadur
, (2019/09/10)
A transition metal free expedient approach for the C[dbnd]C bond cleavage of electron deficient alkenes such as arylidene Meldrum's acid and malononitrile derivatives are discussed. The C[dbnd]C bond of these compound were cleaved to benzoic acid in good yield at high temperature. Most importantly, with oxone in CH3CN/H2O at 45 °C or m-CPBA in DCM or NaClO2 in THF/H2O or PIDA in THF at room temperature furnished benzaldehyde derivatives selectively in excellent yields.
A practical and convenient protocol for the synthesis of (E)-α,β-unsaturated acids
Mohite, Amar R.,Bhat, Ramakrishna G.
supporting information, p. 4564 - 4567 (2013/09/24)
α,β-Unsaturated acids are very useful and versatile reagents in organic synthesis. A novel, practical, and convenient catalytic protocol comprising FeCl3·6H2O (0.5 mol %) and H 2O (1 equiv) in CH3NO2 is described for the rapid synthesis of α,β-unsaturated acids with high E-stereoselectivity under both microwave and conventional heating conditions with high TON and TOF values. This powerful approach efficiently demonstrated the utility of biomass derived aldehydes to build chemical agents used as fuel additives. The method proved to be scalable to gram scale synthesis.
Nickel nanoparticles catalyzed chemoselective Knoevenagel condensation of Meldrum's acid and tandem enol lactonizations via cascade cyclization sequence
Khurana, Jitender M.,Vij, Kanika
experimental part, p. 3666 - 3669 (2011/07/29)
A novel protocol has been reported wherein, polyethylene glycol (PEG) stabilized nickel nanoparticles have been used as catalyst for chemoselective Knoevenagel condensation of aromatic aldehydes and Meldrum's acid to give 5-arylidene Meldrum's acid which underwent tandem enol lactonization by Michael addition/cyclization sequence with active methylene compounds in the presence of Ni nanoparticles to give corresponding enol lactone derivatives.
Reactions of methoxybenzylidene derivatives of 2,2-dimethyl-1,3-dioxane-4, 6-dione and their saturated analogs with certain nucleophilic reagents
Tetere,Ravina,Rijkure,Zicane
scheme or table, p. 1449 - 1453 (2011/12/16)
The reactions of the methoxybenzylidene derivatives of 2,2-dimethyl-1,3- dioxane-4,6-dione and their saturated analogs with potassium hydroxide in methanol, ammonia, and hydrazine hydrate were realized. The 1,2- bis(methoxybenzylidene)hydrazines, amides,
Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents
Sandhu, Harmeet S.,Sapra, Sameer,Gupta, Mukesh,Nepali, Kunal,Gautam, Raju,Yadav, Sunil,Kumar, Raj,Jachak, Sanjay M.,Chugh, Manoj,Gupta, Manish K.,Suri, Om P.,Dhar
experimental part, p. 5626 - 5633 (2010/09/11)
A series of arylidene analogues of Meldrum's acid were synthesized and evaluated for in vitro antimalarial and antioxidant activities for the first time. The influence of various physico-chemical parameters such as dielectric constant (), donor number (DN
Tandem molybdenum catalyzed hydrosilylations: An expedient synthesis of β-aryl aldehydes
Frost, Christopher G.,Hartley, Benjamin C.
, p. 4259 - 4261 (2008/02/12)
The synthesis of β-aryl aldehydes utilizing a tandem molybdenum catalyzed hydrosilylation is described. This new functional group interconversion provides an efficient method for the two-carbon homologation of aryl aldehydes.
Synthesis of substituted 1,2,3,4-tetrahydro-1-thiacarbazole and spiro[pyrrolidinone-3,3′-indolinones] through a common intermediate obtained by condensation of indolin-2-one, (aryl)aldehydes, and Meldrum's acid
Cochard, Fabien,Laronze, Marie,Prost, Elise,Nuzillard, Jean-Marc,Auge, Franck,Petermann, Christian,Sigaut, Philippe,Sapi, Janos,Laronze, Jean-Yves
, p. 3481 - 3490 (2007/10/03)
Trimolecular adducts resulting from condensation between indolin-2-one (or indoline-2-thione), (aryl)aldehydes, and Meldrum's acid are useful intermediates for the synthesis of either 1,2,3,4-tetrahydro-1-thiacarbazoles or spiro[pyrrolidino-3,3′-oxindoles] related to the natural product horsfiline. These latter compounds were obtained in a three-step procedure characterized by acyl azide formation, Curtius rearrangement, and subsequent thermal spiro cyclization. The relative stereochemistry of the spiro derivatives was determined by comparison of NOESY data and calculated conformational analyses. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
SYNTHESIS OF 3-CARBOXYCOUMARINS FROM O-METHOXYBENZYLIDENE MELDRUM'S ACID DERIVATIVES
Armstrong, Veronica,Soto, Oriana,Valderrama, Jaime A.,Tapia, Ricardo
, p. 717 - 726 (2007/10/02)
Reaction of o-methoxybenzaldehydes with Meldrum's acid followed by cyclization in sulfuric acid of the benzylidene derivatives 3a-g affords 3-carboxycoumarins in excellent yields.
