33545-44-7Relevant articles and documents
An approach to 2,4-substituted pyrazolo[1,5-a]pyridines and pyrazolo[1,5-a]azepines by ring-closing metathesis
Fustero, Santos,Roman, Raquel,Asensio, Amparo,Maestro, Miguel A.,Acena, Jose L.,Simon-Fuentes, Antonio
, p. 7164 - 7174 (2013)
The ring-closing metathesis (RCM) reactions of dienylpyrazoles have been employed in the synthesis of pyrazolo[1,5-a]pyridine and pyrazolo[1,5-a]azepine derivatives. Based on this approach, the diastereoselective synthesis of potential peptidomimetics containing four amino acid residues with the second (i+1) and third (i+2) fragments having been substituted by bicyclic frameworks is described. The N-allylation of readily available 3,5-substituted pyrazoles followed by ring-closing metathesis of the resulting 1,5-diolefinic derivatives leads to the formation of 2,4-substituted pyrazolo[1,5-a]pyridines and pyrazolo[1,5-a]azepines in high yields. The application of this protocol to the diastereoselective synthesis of potential peptidomimetics is described. Copyright
Haloacetylated enol ethers, 19: Synthesis of 3-(2-thienyl)- and 3-(2-furyl)-5-trihalomethyl substituted azoles
Flores, Alex F. C.,Brondani, Sergio,Pizzuti, Lucas,Martins, Marcos A. P.,Zanatta, Nilo,Bonacorso, Helio G.,Flores, Darlene C.
, p. 2744 - 2750 (2007/10/03)
Heterocyclization of 1,1,1-trifluoro[chloro]-4-methoxy-4-[2-tienyl]-3- buten-2-one and 1,1,1-trifluoro[chloro]-4-methoxy-4-[2-furyl]-3-buten-2-ones into isoxazoles and pyrazoles derivatives as a new type of trihalomethylated bicyclic heterocycles is reported. Georg Thieme Verlag Stuttgart.