335595-58-9

Upstream product

• 83866-07-3 1-O-methyl-β-D-[1-13C]ribofuranoside 
• 108-24-7 acetic anhydride 

Downstream Products

• 201996-55-6 [1'-13C]adenosine 
• 201996-62-5 (1'-13C)Uridine 
• 201996-57-8 <1'-13C>cytidine 
• 144963-61-1 C₄₇⁽¹³⁾CH₅₄N₇O₉P 
• 144963-60-0 C₄₆⁽¹³⁾CH₅₂N₇O₇P 
• 144963-59-7 C₄₅⁽¹³⁾CH₅₂N₅O₈P 
• 144963-58-6 C₃₉⁽¹³⁾CH₄₉N₄O₈P 
• 144963-53-1 C₃₅⁽¹³⁾CH₄₇N₅O₇SSi₂ 
• 144963-48-4 C₃₆⁽¹³⁾CH₂₉N₃O₉ 
• 144963-52-0 C₃₄⁽¹³⁾CH₄₇N₃O₈SSi₂ 
• 144970-91-2 C₃₀⁽¹³⁾CH₂₆N₂O₉ 
• 144963-51-9 C₂₈⁽¹³⁾CH₄₄N₂O₈SSi₂ 
• 144963-47-3 Phenylsulfenyl <1-(13)C>-2,3,5-tri-O-benzoyl-β-D-ribofuranoside 

Relevant academic research and scientific papers

13C-enriched ribonucleosides: Synthesis and application of 13C-1H and 13C-13C spin-coupling constants to assess furanose and N-glycoside bond conformations

Adenosine (1), cytidine (2), guanosine (3), and uridine (4) have been prepared chemically with 13C enrichment (99 atom %) at C1′ and C2′ of the ribose ring. Reliable synthetic protocols have been developed to permit access to millimole quantities of labeled ribonucleosides required for structural studies of stable isotopically labeled oligonucleotides and for in vivo metabolism studies. High-resolution 1H and 13C NMR spectra of the enriched ribonucleosides have been obtained, and 13C-13C and 13C-1H spin-coupling constants have been measured for pathways within the β-D-ribofuranose ring and across the N-glycoside bond. Related couplings were determined in methyl α- and β-D-ribofuranosides (5, 6), and in two conformationally constrained nucleosides, 2,2′-anhydro-(1-β-D-arabinofuranosyl)uracil (7) and 2′,3′-O-isopropylidene-2,5′-O-cyclouridine (8). The latter data were used to construct a crude Karplus curve for the 13C-C-N-13C coupling pathway across the N-glycoside bond in 1-4. 1H-1H, 13C-1H, and 13C-13C coupling data are used to evaluate current models describing the conformational dynamics of 1-4 in aqueous solution.