144963-48-4

Upstream product

• 26661-13-2 4-N-benzoylcytosine 
• 144963-47-3 Phenylsulfenyl <1-(13)C>-2,3,5-tri-O-benzoyl-β-D-ribofuranoside 
• 380611-22-3 Methyl <1-(13)C>-D-ribofuranoside 
• 83866-07-3 1-O-methyl-D-[1-13C]ribofuranoside 
• 335595-58-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-<1-13C>ribofuranoside 

Downstream Products

• 335595-68-1 C₁₅⁽¹³⁾CH₁₇N₃O₆ 
• 144963-55-3 C₁₅⁽¹³⁾CH₁₇N₃O₅ 
• 144963-52-0 C₃₄⁽¹³⁾CH₄₇N₃O₈SSi₂ 
• 144963-59-7 C₄₅⁽¹³⁾CH₅₂N₅O₈P 
• 335595-68-1 [1'-13C]-N⁴-benzoylcytidine 
• 335595-81-8 [1'-13C]-2'-O-tert-butyldimethylsilyl-N⁴-benzoylcytidine 
• 335595-73-8 [1'-13C]-3',5'-O-(di-tert-butylsilanediyl)-N⁴-benzoylcytidine 
• 335595-78-3 [1'-13C]-2'-O-tert-butyldimethylsilyl-3',5'-O-(di-tert-butylsilanediyl)-N⁴-benzoylcytidine 

Relevant academic research and scientific papers

Synthesis of isotopically labeled D-[1′-13C]ribonucleoside phosphoramidites

The preparation of fully protected labeled diisopropylamino-β-cyanoethyl-[1′-13C]ribonucleoside phosphoramidites with regioisomeric purity is described. We demonstrated in this paper that a regioselective 2′-O-silylation, through a 3′,5′-O-di-tert-butylsilanediyl protection, has been applied for the synthesis of [1′-13C]ribonucleoside phosphoramidite units. This method allowed us to obtain only the desired 2′-O-silyl-3′-O-phosphoramidites avoiding the undesired 3′-O-silyl-2′-O-phosphoramidite nucleosides isolated by standard procedures. This is a suitable procedure to RNA precursors with respect to the isotope-containing precursors.

Phenylsulfenyl D-Ribofuranosides as Efficient Ribosyl Donors: Application to the Synthesis of -(Deoxy)Nucleosides

Readily available phenylsulfenyl 2,3,5-tri-O-benzoyl-β-D-ribofuranoside glycosylates silylated nucleobases in a fast, high-yielding and stereoselective reaction promoted by trimethylsilyl trifluoromethanesulfonate.The method has been applied to the synthesis of labelled nucleosides further transformed to building blocks ready for oligodeoxynucleotide construction. Key words: anomeric sulfoxides; silylated nucleobases; nucleosides; 2'-deoxynucleosides.