335654-07-4

Basic information

• Product Name: 5,5-dibromo-2-chloro-5H-pyrrolo[2,3-d]pyrimidin-6(7H)-one
• CAS NO: 335654-07-4
• Molecular Weight: 327.362
• Mol File: 335654-07-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5,5-dibromo-2-chloro-5H-pyrrolo[2,3-d]pyrimidin-6(7H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5-dibromo-2-chloro-5H-pyrrolo[2,3-d]pyrimidin-6(7H)-one(335654-07-4)
• EPA Substance Registry System: 5,5-dibromo-2-chloro-5H-pyrrolo[2,3-d]pyrimidin-6(7H)-one(335654-07-4)

Safety Data

• Hazardous Substances Data: 335654-07-4(Hazardous Substances Data)

Upstream product

• 335654-06-3 2-chloro-7H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 335654-08-5 2-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one 
• 5817-96-9 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one 

Relevant articles and documents

Synthesis of 2-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

1,3-Dihydro-2H-indol-2-ones (oxindoles) and 1,3-dihydro-2H-pyrrolopyridin-2-ones (azaoxindoles) are useful scaffolds that have been explored for various pharmaceutical uses. Herein we report the synthesis of 2-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin

FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS

The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula (I) where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.

Indolin-2-one p38α inhibitors II: Lead optimisation

Optimisation of a series of indolin-2-one p38α inhibitors was achieved via both blocking of a potential metabolic 'hot spot' and by increasing overall polarity of the lead series leading to non-cytotoxic compounds which showed improved oral bioavailabilities in the rat.