335654-07-4Relevant academic research and scientific papers
Synthesis of 2-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one
Cheung, Mui,Harris, Philip A.,Lackey, Karen E
, p. 999 - 1001 (2001)
1,3-Dihydro-2H-indol-2-ones (oxindoles) and 1,3-dihydro-2H-pyrrolopyridin-2-ones (azaoxindoles) are useful scaffolds that have been explored for various pharmaceutical uses. Herein we report the synthesis of 2-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin
cGAS ANTAGONIST COMPOUNDS
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Paragraph 0381, (2017/11/06)
Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
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Paragraph 0179, (2016/11/14)
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula (I) where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.
NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS
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Page/Page column 56, (2015/02/25)
Novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
Indolin-2-one p38α inhibitors II: Lead optimisation
Eastwood, Paul,González, Jacob,Gómez, Elena,Caturla, Francisco,Balagué, Cristina,Orellana, Adelina,Domínguez, María
scheme or table, p. 5270 - 5273 (2011/10/09)
Optimisation of a series of indolin-2-one p38α inhibitors was achieved via both blocking of a potential metabolic 'hot spot' and by increasing overall polarity of the lead series leading to non-cytotoxic compounds which showed improved oral bioavailabilities in the rat.
