3357-31-1

Upstream product

• 77-78-1 dimethyl sulfate 
• 38942-51-7 3-mercapto-4-methyl-5-phenyl-1,2,4(4H)-triazole 
• 98-88-4 benzoyl chloride 
• 108-86-1 bromobenzene 
• 1417450-01-1 5-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazole 
• 420-37-1 trimethoxonium tetrafluoroborate 
• 58064-65-6 1-(phenyl)carbonyl-4-(methyl)thiosemicarbazide 
• 63182-88-7 N,S-Dimethylthiobenzamidiumiodid 
• 3357-42-4 3-phenyl-1,2,4-triazole 
• 64-18-6 formic acid 
• 83274-33-3 N³-methylbenzamidrazonium iodide 
• 38942-51-7 4-methyl-3-phenyl-1H-1,2,4-triazole-5(4H)-thione 

Downstream Products

• 881845-15-4 4-methyl-5-phenyl-4H-1,2,4-triazol-3-ylmethanol 
• 219600-03-0 4-methyl-5-phenyl-4H-1,2,4-triazole-3-carbaldehyde 
• 1408232-02-9 1-(di-tert-butylphosphino)-4-methyl-3-phenyl-4H-1,2,4-triazol-1-ium trifluoromethanesulfonate 
• 1408232-04-1 3-(di-tert-butylphosphino)-4-methyl-5-phenyl-4H-1,2,4-triazole 
• 1408232-05-2 3-(di-tert-butylphosphoroselenoyl)-4-methyl-5-phenyl-4H-1,2,4-triazole 
• 1408232-06-3 2-(di-tert-butylphosphino)-4-methyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-selone 
• 1408232-07-4 2-(di-tert-butylphosphoroselenoyl)-4-methyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-selone 
• 1408232-03-0 1-(di-tert-butylphosphino)-4-methyl-3-phenyl-1,2,4-triazol-5-ylidene 
• 471910-31-3 3-(4-methoxyphenyl)-4-methyl-5-phenyl-4H-1,2,4-triazole 

Relevant academic research and scientific papers

C-H bonds as ubiquitous functionality: Preparation of multiple regioisomers of arylated 1,2,4-triazoles via C-H arylation

We describe a general approach for the synthesis of complex aryl 1,2,4-triazoles. The electronic character of the C-H bonds and the triazole ring allows for the regioselective C-H arylation of 1-alkyl- and 4-alkyltriazoles under catalytic conditions. We have also developed the SEM and THP switch as well as trans-N-alkylation, which enable sequential arylation of the triazole ring to prepare 3,5-diaryltriazoles. This new strategy provides rapid access to a variety of arylated 1,2,4-triazoles and well complements existing cyclization methods.

A convenient synthesis of 4,5-disubstituted 1,2,4-triazoles functionalized in position 3

A convenient approach to 4,5-disubstituted 3-hydroxymethyl-1,2,4-triazoles as well as to the corresponding 3-chloromethyl and 3-carboxaldehyde derivatives was developed starting from 3-mercapto-1,2,4-triazoles which can, in turn, be readily obtained from

Catalysis and regioselectivity in the Michael addition of azoles. Kinetic vs. thermodynamic control

Bicyclic guanidine bases, TBD and MTBD were found to be high]y efficient catalysts in the Michael addition of azoles with α,β-unsaturated nitriles and esters. The factors influencing regioselectivity have been elucidated, and some new azole-Michael adduct

Synthesis of 1,2,4-Triazines, IX. Synthesis of Cyclopenta-1,2,4-triazines

Derivatives 12a - f and 23a - c of hitherto unknown cyclopenta-1,2,4-triazine system 1 were prepared from cyclopentadienedicarboxylates 9a,b and amidrazones 10a - d or 14a - c, respectively.