33583-12-9

Basic information

• Product Name: 10-phenylpyrido[1,2-a]indole
• Synonyms: 10-phenylpyrido[1,2-a]indole
• CAS NO: 33583-12-9
• Molecular Weight: 243.308
• Mol File: 33583-12-9.mol

Chemical Properties

• CAS DataBase Reference: 10-phenylpyrido[1,2-a]indole(CAS DataBase Reference)
• NIST Chemistry Reference: 10-phenylpyrido[1,2-a]indole(33583-12-9)
• EPA Substance Registry System: 10-phenylpyrido[1,2-a]indole(33583-12-9)

Safety Data

• Hazardous Substances Data: 33583-12-9(Hazardous Substances Data)

Upstream product

• 76160-38-8 (2-bromophenyl)(pyridin-2-yl)methanol 
• 6630-33-7 ortho-bromobenzaldehyde 
• 2524-52-9 ethyl-2-picolinate 
• 108-86-1 bromobenzene 
• 19490-90-5 diphenyl(2-pyridyl)methanol 
• 1121-60-4 pyridine-2-carbaldehyde 
• 3678-70-4 Diphenyl-2-pyridylmethan 
• 31796-72-2 phenyl(2-pyridinyl)methanol 
• 1346508-93-7 1-allyl-3-hydroxy-3-phenylindolin-2-one 
• 91-56-5 indole-2,3-dione 

Relevant articles and documents

General synthesis of pyrido[1,2-a]indoles via Pd-catalyzed cyclization of o-picolylbromoarenes

An efficient Pd-catalyzed cyclization of o-picolylbromoarenes into pyridoindoles has been developed. This novel transformation, which proceeds through a not common for Pd catalysis L-to X-type pyridine ligand swap, provides an efficient route to aryl-, as well as to cyanopyrido[1,2-a]indoles, not easily accessible by existing cyclization methods.

Divergent and Orthogonal Approach to Carbazoles and Pyridoindoles from Oxindoles via Indole Intermediates

The previously unexplored Grignard addition to oxindoles provides a regiospecific approach to 2- and 2,3-disubstituted indole derivatives in high yields via a one-pot aromatization driven dehydration pathway. This method allows a convenient preparation of diallyl indoles that are used as ring-closing metathesis (RCM) precursors for the orthogonal synthesis of pyrido[1,2-a]indoles and carbazoles. The synthetic utility of this method is illustrated by the synthesis of a microtubulin inhibitor and naturally occurring carbazole alkaloids.

An efficient synthesis of pyrido[1,2-a]indoles through aza-Nazarov type cyclization

Transition metal free Br?nsted acid mediated synthesis of biologically important pyrido[1,2-a]indole scaffolds through aza-Nazarov type cyclization of readily available diaryl(2-pyridyl)methanol using formic acid has been developed. This methodology has b

Iron-catalyzed C-H bond functionalization for the exclusive synthesis of pyrido[1,2-a]indoles or triarylmethanols

The efficient and selective iron-catalyzed C-H activation of 2-benzhydrylpyridine derivatives was employed for the preparation of pyrido[1,2-a]indoles through an intramolecular C-H amination reaction. In the presence of molecular oxygen as the sole oxidant, the same 2-benzhydrylpyridines were also used for the synthesis of the corresponding tertiary alcohols. In these approaches, the iron catalyst was used to selectively activate the C(sp2)-H bond of 2-benzhydrylpyridine, in the case of the intramolecular ring-closing C-H amination reaction in which the pyridine nitrogen atom was a directing group as well as a nucleophile, and the C(sp3)-H bond of the same compound, in the case of the oxidation reaction to give the corresponding triaryl carbinol.