3359-05-5Relevant academic research and scientific papers
Synthesis and antimicrobial activities of structurally novel S,S′-bis(heterosubstituted) disulfides
Ramaraju, Praveen,Gergeres, Danielle,Turos, Edward,Dickey, Sonja,Lim, Daniel V.,Thomas, John,Anderson, Burt
experimental part, p. 3623 - 3631 (2012/07/16)
The central focus of this study is on the antibacterial and antifungal properties of synthetically produced S,S′-bis(heterosubstituted) disulfides as a means to control the growth of various infection-causing pathogens. Staphylococcus aureus, Francisella tularensis and Candida albicans were each found to be highly susceptible to several of these compounds by agar or broth dilution and Kirby-Bauer diffusion assays. These structurally simple, low molecular weight disulfides have shown promising bioactivities and may serve as leads to the development of effective new antibacterials for pathogenic bacteria such as methicillin-resistant S. aureus and F. tularensis.
ANTIBACTERIAL S-HETEROSUBSTITUTED DISULFIDES
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Page/Page column 13, (2009/05/30)
Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.
