33597-94-3Relevant academic research and scientific papers
A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent
Anselmi, Silvia,Liu, Siyu,Kim, Seong-Heun,Barry, Sarah M.,Moody, Thomas S.,Castagnolo, Daniele
, p. 156 - 161 (2021/01/14)
A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.
Nickel-Catalyzed Highly Enantioselective Hydrogenation of β-Acetylamino Vinylsulfones: Access to Chiral β-Amido Sulfones
Long, Jiao,Gao, Wenchao,Guan, Yuqing,Lv, Hui,Zhang, Xumu
supporting information, p. 5914 - 5917 (2018/09/25)
The nickel/(S)-Binapine complex was found to be an efficient catalyst for asymmetric hydrogenation of β-acetylamino vinylsulfones to afford chiral β-Amido sulfones with excellent yields and enantioselectivities (up to 95% yields and >99% ee). This protocol has good compatibility with a series of substituted (Z)-β-acetylamino vinylsulfones or Z/E isomeric mixtures. A gram-scale reaction has also been achieved in the presence of a 0.2 mol % catalyst loading.
A 1,3-diones substitution alkone method of synthesizing α-
-
Paragraph 0033; 0034; 0035; 0036; 0037; 0038, (2016/10/10)
The invention discloses a method for synthesizing alpha-substituted ketone by using a 1,3-diketone compound, and belongs to the field of preparation of fine chemical engineering. The 1,3-diketone compound with an electron-withdrawing substituent group at 2-position is used as a substrate, an accelerant is added, and alpha-substituted ketone is synthesized by utilizing mixed solvent of tetrahydrofuran and water. An efficient and single method for synthesizing the alpha-substituted ketone, which is mild in condition, low in cost and suitable for large-scale production is provided.
β-Keto sulfones as inhibitors of 11β-hydroxysteroid dehydrogenase type I and the mechanism of action
Xiang, Jason,Ipek, Manus,Suri, Vipin,Tam, May,Xing, Yuzhe,Huang, Nelson,Zhang, Yanling,Tobin, James,Mansour, Tarek S.,McKew, John
, p. 4396 - 4405 (2008/03/12)
The design, synthesis, and biological evaluation of β-keto sulfones as 11β-HSD1 inhibitors and the mechanism of inhibition are described here. This class of compounds is not active against 11β-HSD2 and therefore may have therapeutic potential for metabolic syndrome and type 2 diabetes.
Enantioselective hydrogenation of β-keto sulfones with chiral Ru(II)- catalysts: Synthesis of enantiomerically pure butenolides and γ- butyrolactones
Bertus,Phansavath,Ratovelomanana-Vidal,Genet,Touati,Homri,Hassine, B. Ben
, p. 1369 - 1380 (2007/10/03)
A series of β-hydroxy sulfones were synthesized with high enantioselectivities via a new enantioselective ruthenium-catalyzed hydrogenation using MeO-BIPHEP as a ligand. Some β-hydroxy sulfones were used in the synthesis of optically active butenolides and γ-butyrolactones with high yields and enantioselectivities over 95%.
CHEMISTRY OF BAKER'S YEAST REDUCTION PRODUCTS: USE OF OPTICALLY ACTIVE (S)-(+)-1-(p-TOLUENESULFONYL)PROPAN-2-OL AND (S)-(+)-1-(PHENYLSULFONYL)PROPAN-2-OL IN SYNTHESIS.
Kozikowski, Alan P.,Mugrage, B.B.,Li, C.S.,Felder, L.
, p. 4817 - 4820 (2007/10/02)
The utility of the title compounds in the preparation of optically active lactones and alcohols is detailed.
