3360-69-8Relevant academic research and scientific papers
Synthesis of α-aminophosphonates using solvate ionic liquids
Eyckens, Daniel J.,Henderson, Luke C.
, p. 27900 - 27904 (2017/07/07)
A range of α-aminophosphonates were accessed in high yields and very rapidly, using solvate ionic liquids as the reaction media. Reactions typically required less than 10 minutes to go to completion and precipitation of these products into water excludes the use of traditional work up procedures, giving the products in very high crude purity. Excellent functional group tolerance for both the aldehyde and amine reaction partners was observed, and a range of bis-aminophosphonates derived from aromatic diamines were also accessed in high yield and purity.
A new, efficient and recyclable [Ce(l-Pro)]2(Oxa) heterogeneous catalyst used in the Kabachnik-Fields reaction
Da Silva, Caren D. G.,Oliveira, Aline R.,Rocha, Mariana P. D.,Katla, Ramesh,Botero, Eriton Rodrigo,Da Silva, érica C.,Domingues, Nelson Luís C.
, p. 27213 - 27219 (2016/03/25)
Herein we introduce a new catalyst for the Kabachnik-Fields reaction, [Ce(l-Pro)]2(Oxa), using a very accessible, simple and efficient methodology for α-aminophosphonate synthesis using an aromatic aldehyde, an aromatic amine and diphenyl phosphite. This procedure was developed using a low catalyst loading of cerium(iii) prolinate and it has allowed for the recycling of the catalyst.
Zinc Di(l-prolinate)-Mediated Synthesis of α-Aminophosphonates under Mild Conditions
De Oliveira, Aline R.,Katla, Ramesh,Rocha, Mariana P. D.,Albuquerque, Tábata B.,Da Silva, Caren D. G.,Kupfer, Vicente L.,Rinaldi, Andrelson W.,Domingues, Nelson Luís Campos
, p. 4489 - 4494 (2016/12/16)
An efficient method has been developed for the preparation of α-aminophosphonates by using zinc di(l-prolinate) as a catalyst under mild reaction conditions. The method has the advantages of high yields, short reaction times, and easy workup conditions.
A Quick and Clean Procedure for Synthesis of α-Aminophosphonates in Aqueous Media
Mollashahi, Ebrahim,Gholami, Hamideh,Kangani, Mehrnoosh,Lashkari, Mojtaba,Maghsoodlou, Malek Taher
, p. 322 - 328 (2015/03/30)
A green and efficient procedure for the synthesis of α-aminophosphonates has been developed in water as a green and nonhazardous solvent, from condensation between aromatic aldehydes, aniline, and triphenyl phosphite at 80°C. This methodology has a number
A novel and efficient synthesis of α-aminophosphonates by use of triphenyl phosphite in acetic acid media
Rostamizadeh, Mohsen,Maghsoodlou, Malek Taher,Hazeri, Nourallah,Habibi-Khorassani, Sayyed Mostafa,Keishams, Leila
experimental part, p. 334 - 337 (2011/04/24)
Chemical Equation Presented For the first time, α-aminophosphonates were obtained by a simple and efficient one-pot method from the reaction between aldehyde, aniline, and triphenyl phosphite in the presence of acetic acid as a catalyst and solvent at roo
1,2-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND PHARMACEUTICAL COMPOSITIONS THEREOF
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Page/Page column 102, (2010/02/15)
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula (I), or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the application.
1,2,3-thiadiazole compounds, compositions and method of anti-thrombotic treatment
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, (2008/06/13)
Novel 1,2,3-thiadiazole compounds, new and old 1,2,3-thiadiazole compositions and method of anti-thrombotic treatment are systemically administered to a human or animal.
SUBSTITUENT EFFECTS ON THE 31P, 13C, AND 1H NMR CHEMICAL SHIFTS OF SUBSTITUTED DIPHENYL 1-PHENYLAMINO-1-PHENYLMETHANEPHOSPHONATES AND THEIR ANIONS
Smith, Scott J.,Zimmer, Hans,Fluck, Ekkehard,Fischer, Peter
, p. 105 - 120 (2007/10/02)
For a series of thirty-five novel diphenyl 1-phenylamino-1-phenylmethanephosphonates, substituted in the meta and para positions on the anilino and/or aryl ring, 31P chemical shifts show a good linear correlation with Hammett ?n and Taft ?0 parameters, the 31P nucleus being better shielded in the case of electron withdrawing substituents.The same pattern is observed for the phosphonate anions, except when para phenyl substituents can interact with the phosphorus atom by direct resonance.This inverse relationship is due to a field effect of the substituent dipole which polarizes ?-electron clouds in the molecule.A corresponding shift in ?-electron density is likewise observed for 13C resonances of the two diastereotopic phenoxy groups, the phenylamino and phenyl moieties.Vicinal CH-NH coupling is shown to be dependent on the rate of NH proton exchange as influenced by resonance, temperature and solvent effects.
