336183-01-8

Upstream product

• 19790-60-4 3-Benzyloxypropanal 
• 479483-97-1 (2S,3R)-5-Benzyloxy-3-hydroxy-2-methyl-pentanoic acid (S)-3-methyl-2-(toluene-4-sulfonylamino)-butyl ester 
• 198962-86-6 (2S,3R)-5-Benzyloxy-3-hydroxy-2-methyl-pentanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)-indan-2-yl ester 
• 336182-90-2 (2S,3R)-5-Benzyloxy-3-hydroxy-2-methyl-pentanoic acid (S)-3-phenyl-2-(toluene-4-sulfonylamino)-propyl ester 

Downstream Products

• 350256-95-0 methyl (2S,3R)-5-benzyloxy-3-hydroxy-2-methylpentanoate 

Relevant academic research and scientific papers

Chelation-controlled ester-derived titanium enolate aldol reaction: Diastereoselective syn-aldols with mono- and bidentate aldehydes

A chelation-controlled and highly diastereoselective synthesis of syn-aldols is described. Aldol reaction of (S)-valinol-derived ester with a variety of aldehydes proceeded with high syn-diastereoselectivities (up to 99:1) and isolated yields (94%).

Ester derived titanium enolate aldol reaction: Chelation controlled diastereoselective synthesis of syn-aldols

A chelation controlled and highly diastereoselective synthesis of syn-aldols is described. Aldol reaction of commercially available L-phenylalaninol derived esters with a variety of bidentate oxyaldehydes proceeded with excellent syn-diastereoselectivities and isolated yields.

Ester derived titanium enolate aldol reaction: Highly diastereoselective synthesis of syn- and anti-aldols

Aldol reactions of bidentate aldehydes and cis-1-arylsulfonamido-2-indanyl ester derived titanium enolates proceed with excellent syn-diastereoselectivities and good to excellent isolated yields.