350256-95-0Relevant academic research and scientific papers
Chelation-controlled ester-derived titanium enolate aldol reaction: Diastereoselective syn-aldols with mono- and bidentate aldehydes
Ghosh, Arun K,Kim, Jae-Hun
, p. 5621 - 5624 (2002)
A chelation-controlled and highly diastereoselective synthesis of syn-aldols is described. Aldol reaction of (S)-valinol-derived ester with a variety of aldehydes proceeded with high syn-diastereoselectivities (up to 99:1) and isolated yields (94%).
Enantio- and diastereoselective reductive aldol reactions with iridium-pybox catalysts
Zhao, Cun-Xiang,Duffey, Matthew O.,Taylor, Steven J.,Morken, James P.
, p. 1829 - 1831 (2007/10/03)
(formula presented) A catalytic amount of [(cod)IrCl]2 and indane-pybox converts diethylmethylsilane, methyl acrylate, and certain aldehydes to the derived reductive aldol adduct with good enantio- and diastereocontrol.
