3362-42-3

Basic information

• Product Name: Methanone, diphenyl-, O-[2-(dimethylamino)ethyl]oxime
• CAS NO: 3362-42-3
• Molecular Formula: C17H20N2O
• Molecular Weight: 268.359
• Mol File: 3362-42-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Methanone, diphenyl-, O-[2-(dimethylamino)ethyl]oxime(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, diphenyl-, O-[2-(dimethylamino)ethyl]oxime(3362-42-3)
• EPA Substance Registry System: Methanone, diphenyl-, O-[2-(dimethylamino)ethyl]oxime(3362-42-3)

Safety Data

• Hazardous Substances Data: 3362-42-3(Hazardous Substances Data)

Upstream product

• 574-66-3 Benzophenone oxime 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 107-99-3 2-(dimethylamino)ethyl chloride 

Downstream Products

• 2848-78-4 2-(N,N-dimethylamino)ethoxyamine dihydrochloride 

Relevant articles and documents

Synthesis and affinity for serotonin and dopamine transporters of some benzophenone oxime ether derivatives

In a previous study, we reported the synthesis of several 3-(methylenaminoxymethyl)-substituted piperidine derivatives and their ability to interfere with the transmission mediated by biogenic amines. The present study describes the preparation of some ne

17β-O-aminoalkyloximes of 5β-androstane-3β, 14β-diol with digitalis- like activity: Synthesis, cardiotonic activity, structure-activity relationships, and molecular modeling of the Na+,K+-ATPase receptor

A series of digitalis-like compounds with a 17-aminoalkoxyiminoalkyl or -alkenyl substituent was synthesized and evaluated for inhibition of Na+,K+-ATPase and for inotropic activity. The highest inhibition was found with compounds having the substituent in configuration 17β and the amino group at a distance of 6 or 7 bonds from C(17) of the digitoxigenin skeleton. The presence of the oxime function strengthens the interaction with the receptor, more if α,β-unsaturated, thus mimicking the electronic situation of the unsaturated lactone in natural digitalis compounds. The most active compounds showed Na+,K+-ATPase inhibitory potencies (IC50) 17-25 times higher than the standards digitoxigenin and digoxin and 3-11 times higher inotropic potencies (EC50) in isolated guinea pig left atria. These features are supported by a molecular model suggesting the possible interactions of the groups described above with particular amino acid residues in the H1-H2 domains of Na+,K+-ATPase. Some interactions are the classical ones already described in the literature; a new, very strong interaction of the basic group with the Cys138 was found and adds new possibilities to design compounds interacting with this region of the receptor. The most interesting compounds were also studied in vivo in the anesthetized guinea pig for evaluating their inotropic effect versus the lethal dose. Compounds 9 and 12 showed a slightly higher safety ratio than digoxin and deserve further evaluation.

Synthesis of oxime esters and ethers as potential psychotropic agents.

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