33626-67-4Relevant academic research and scientific papers
Experimental and computational spectroscopic studies of 3,5-disubstituted 4,5-dihydro-1,2,4-oxadiazoles
Asgari, Mehrnoosh,Memarian, Hamid R.,Sabzyan, Hassan
, (2020/02/11)
Some 3,5-disubstituted 4,5-dihydro-1,2,4-oxadiazoles (DHOZs) were synthesized, and steric and electronic effects of the substituents on the heterocyclic ring C3- and C5-positions were investigated using the NMR and UV–Vis spectroscopies, and (TD)DFT/6-311
Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles from Amidoximes and Aldehydes in the Superbasic System NaOH/DMSO
Korsakov, M. K.,Kotov, A. D.,Kunichkina, A. S.,Pankratieva, V. E.,Proskurina, I. K.,Shetnev, A. A.,Vlasov, A. S.
, p. 1181 - 1186 (2020/10/02)
Abstract: A new procedure has been proposed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles by reaction of amidoximes with aldehydes in the superbasic system NaOH/DMSO at room temperature. The scope of the proposed procedure has been demonstrated by 15 syntheses from various amidoximes and aromatic aldehydes with 27–76% yields. The procedure is inapplicable to aliphatic aldehydes.
Gold-Catalyzed Formal [3 + 2] Cycloaddition of Ynamides with 4,5-Dihydro-1,2,4-oxadiazoles: Synthesis of Functionalized 4-Aminoimidazoles
Xu, Wei,Wang, Gaonan,Sun, Ning,Liu, Yuanhong
supporting information, p. 3307 - 3310 (2017/06/23)
A gold-catalyzed formal [3 + 2] cycloaddition of ynamides with 4,5-dihydro-1,2,4-oxadiazoles has been developed. The reaction provides a concise and regioselective access to highly functionalized 4-aminoimidazoles likely via the formation of an α-imino go
Base-mediated one-pot synthesis of 1,2,4-oxadiazoles from nitriles, aldehydes and hydroxylamine hydrochloride without addition of extra oxidant
Wang, Wei,Xu, Hao,Xu, Yuanqing,Ding, Tao,Zhang, Wenkai,Ren, Yanrong,Chang, Haibo
supporting information, p. 9814 - 9822 (2016/10/31)
A simple base-mediated one-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from nitriles, aldehydes and hydroxylamine hydrochloride has been developed, in which the aldehydes act as both substrates and oxidants. The reactions include three sequential
Oxidative radical skeletal rearrangement induced by molecular oxygen: Synthesis of quinazolinones
Wang, Yi-Feng,Zhang, Feng-Lian,Chiba, Shunsuke
supporting information, p. 2842 - 2845 (2013/07/11)
Oxidative skeletal rearrangement of 5-aryl-4,5-dihydro-1,2,4-oxadiazoles into quinazolinones is induced by molecular oxygen (under a dry air atmosphere) that likely proceeds via transient iminyl radical species. Concise syntheses of biologically active qu
