33630-87-4

Usage

Uses

Used in Research Applications:
1-Azabicyclo[2.2.2]oct-2-ene-3-carboxylic acid methyl ester hydrochloride is used as a research chemical for studying the effects and mechanisms of action of synthetic cathinones on the central nervous system. Its powerful stimulating properties make it a valuable tool for understanding the neurochemical pathways involved in stimulant abuse and addiction.
Used in Pharmaceutical Development:
Although MDPV has a high potential for abuse, its potent stimulating effects may be harnessed for the development of new pharmaceuticals under strict regulatory control and proper medical supervision. Its effects on alertness and sensory perception could potentially be utilized in the treatment of certain medical conditions, such as attention deficit hyperactivity disorder (ADHD) or narcolepsy, where stimulant medications are currently used.
Used in Forensic Toxicology:
1-Azabicyclo[2.2.2]oct-2-ene-3-carboxylic acid methyl ester hydrochloride is also used in forensic toxicology for the identification and analysis of synthetic cathinones in biological samples. Its unique chemical structure and properties make it a target compound for the detection of drug abuse and intoxication cases involving synthetic stimulants.

InChI:InChI=1/C9H13NO2.ClH/c1-12-9(11)8-6-10-4-2-7(8)3-5-10;/h6-7H,2-5H2,1H3;1H

Upstream product

• 57598-88-6 3-hydroxy-3-methoxycarbonyl-1-azabicyclo[2.2.2]octane 

Relevant academic research and scientific papers

Preparation of quinuclidine-3-methanol

A process for the preparation of quinuclidine-3-methanol comprising reacting quinuclidine-3-one acid addition salt with an alkali metal cyanide in an aqueous media to obtain 3-cyano-3-hydroxy-quinuclidine, reacting the latter with anhydrous methanol in the presence of hydrogen chloride gas followed by treatment with aqueous alkali to obtain methyl 3-hydroxy-quinuclidine-3-carboxylate, reacting the latter with thionyl chloride to form methyl 1-azabicyclo(2,2,2)oct-2-ene-3-carboxylate, hydrogenating the latter with Raney nickel to obtain methyl 1-azabicyclo(2,2,2)octane-3-carboxylate and reducing the latter to obtain quinuclidine-3-methanol which is an intermediate for mequitazine which is useful as an antihistaminic.

Imidazole derivatives and salts thereof and pharmaceutical formulations useful in thrombo-embolic disorders

Imidazoles of formula (I) STR1 wherein A is a chemical bond or a straight or branched, saturated or unsaturated, aliphatic residue having from 1 to 6 carbon atoms wherein 1, 2 or 3 of such carbon atoms may be replaced by a corresponding number of heteroatoms selected from oxygen, sulphur and nitrogen providing (in the case of 2 or 3 heteroatoms) that any such heteroatom is not located adjacent to a further such heteroatoms or heteroatoms R is a fused, saturated or unsaturated, non-aromatic carbocyclic, polycyclic ring system; a saturated or unsaturated, carbocyclic spirocyclic ring system, optionally containing one or more ring heteroatoms selected from oxygen, sulphur and nitrogen; or a saturated or unsaturated, carbocyclic bridged-polycyclic ring system, optionally containing one or more ring heteroatoms selected from oxygen, sulphur and nitrogen and having one or more bridges; or AR together represent a straight or branched, saturated or unsaturated, aliphatic residue having 3 to 6 carbon atoms, wherein 1, 2 or 3 of such carbon atoms may be replaced by a corresponding number of heteroatoms selected from oxygen, sulphur and nitrogen providing (in the case of 2 or 3 heteroatoms) that any such heteroatom is not located adjacent to a further such heteroatom or heteroatoms; which aliphatic residue is substituted by at least two groups, which may be the same or different, selected from the groups specified for R above. and acid addition salts and pharmaceutically acceptable bioprecursors thereof. Methods of preparing the imidazoles are disclosed. The imidazoles and their acid addition salts and bioprecursors are useful in the treatment or prophylaxis of thrombo-embolic conditions.