33662-35-0

Upstream product

• 2161-40-2 2-methoxytropone 
• 33816-51-2 5-bromo-2-methoxycyclohepta-2,4,6-trien-1-one 

Downstream Products

• 103539-19-1 2,4-dibromo-7-(2-hydroxyanilino)tropone 
• 29798-82-1 2,4,7-tribromotropone 
• 103539-22-6 2,4-dibromo-7-(2-methoxyanilino)tropone 

Relevant academic research and scientific papers

An Improved Synthesis of 2,7-Dihydroxytropone (3-Hydroxytropolone)

2,7-Dihydroxytropone is efficiently prepared from 2-methoxytropone by bromination with N-bromosuccinimide, reaction of the resultant 2-bromo-7-methoxytropone with acetyl trifluoroacetate in situ, and hydrolysis of the 2,7-diacetoxytropone thus obtained with aqueous acetic acid.The intermediacy of a 2-acetoxy-1-bromo-3-methoxytropylium salt in the acetoxylation step is suggested.

TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS

Disclosed are a series of compounds or their tautomers having a general structure represented by Formula (la), (lb), (Ila), (lIb), or (lIc) and pharmaceutically acceptable salts thereof. The present disclosure also relates to pharmaceutical compositions comprising said compounds or tautomers. The present disclosure further relates to a method of treating a disease or condition associated with iron dysregulation or dysfunctional iron homeostasis comprising administering to a subject in need thereof a therapeutically effective amount of Formula (la), (lb), (Ila), (lIb), or (lIc) compounds or tautomers.