33667-82-2

Basic information

• Product Name: 1-chloro-2-(phenylsulfanyl)benzene
• CAS NO: 33667-82-2
• Molecular Formula: C₁₂H₉ClS
• Molecular Weight: 220.7179
• Mol File: 33667-82-2.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 295.9°C at 760 mmHg
• Flash Point: 127.9°C
• Density: 1.25g/cm³
• Vapor Pressure: 0.00261mmHg at 25°C
• Refractive Index: 1.652
• CAS DataBase Reference: 1-chloro-2-(phenylsulfanyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-2-(phenylsulfanyl)benzene(33667-82-2)
• EPA Substance Registry System: 1-chloro-2-(phenylsulfanyl)benzene(33667-82-2)

Safety Data

• Hazardous Substances Data: 33667-82-2(Hazardous Substances Data)

Usage

Molecular structure

Benzene derivative with a chlorine atom and a phenylsulfanyl (thiophenyl) group attached to adjacent carbon atoms

Applications

a. Organic synthesis
b. Pharmaceutical research
c. Building block for more complex molecules

Chemical reactions

a. Substitution reactions
b. Addition reactions

Potential applications

a. Pharmaceutical industry
b. Agrochemical industry
c. Material science

Precursors

Used in the synthesis of pharmaceuticals

Additional uses

Production of dyes and pigments

Safety precautions

Handle with caution due to potential toxic and irritant properties

Upstream product

• 108-98-5 thiophenol 
• 95-50-1 1,2-dichloro-benzene 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 71-43-2 benzene 
• 3900-89-8 2-Chlorobenzeneboronic acid 
• 882-33-7 diphenyldisulfane 
• 615-41-8 2-iodochlorobenzene 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 13524-04-4 2'-chloro-sec-phenethyl alcohol 
• 873-55-2 sodium benzenesulfonate 
• 6320-03-2 2-chlorothiphenol 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 62-53-3 aniline 

Downstream Products

• 869854-44-4 1-(4-((2-chlorophenyl)thio)phenyl)ethan-1-one 
• 23156-74-3 2-hydroxydiphenylsulfone 
• 17051-72-8 (o-chlorophenyl)phenylsulfone 

Relevant articles and documents

Environmentally Friendly and Recyclable CuCl 2-Mediated C-S Bond Coupling Strategy Using DMEDA as Ligand, Base, and Solvent

Simple reaction conditions and recyclable reagents are crucial for environmentally friendly industrial applications. An environment-friendly, recyclable and economic strategy was developed to synthesize diaryl chalcogenides by the CuCl2-catalyzed C S bondformation reaction via iodobenzenes and benzenethiols/1,2-diphenyldisulfanes using N,N'-dimethylethane-1,2-diamine (DMEDA) as ligand, base, and solvent. For these reactions, especially the reactions of diiodobenzenes and aminobenzenethiols/disulfanediyldianilines, a range of substrates are compatible and give the corresponding products in good to excellent yields. Both of the reagents in the catalytic system (CuCl2/DMEDA) are inexpensive, conveniently separable, and recyclable for more than five cycles.

DABCO-promoted Diaryl Thioether Formation by Metal-catalyzed Coupling of Sodium Sulfinates and Aryl Iodides

A scalable catalytic synthesis method using commodity chemicals for constructing diaryl thioethers directly from sodium arylsulfinates and iodoarenes is reported in this study. In the presence of CuO or other copper salts such as Cu(OAc)2 as well as palladium catalysts, DABCO demonstrated to be essential to promote this transformation. Various iodoarenes and aryl sulfinates were examined and demonstrated the viability of this method. The mechanistic study showed that radical reactions occurred, while DABCO N-oxide radical can be observed by mass spectrometry. A plausible catalytic mechanism involving DABCO is also discussed, suggesting synergistic reduction of sulfinate by Cu(II) and DABCO is the key step of this coupling reaction. (Figure presented.).

Bimetallic BaMoO4 nanoparticles for the C-S cross-coupling of thiols with haloarenes

We disclosed new bimetallic BaMoO4 nanoparticles for the C-S cross-coupling reaction. The C-S cross-coupling reaction of alkyl/aryl thiols with haloarenes was accomplished with high yields. The reaction has good functional group tolerance and selectivity. This is an efficient protocol for synthesizing the building blocks of pharmaceuticals containing C-S bonds. The catalyst is recyclable. The unactivated bromo- and 4-acetyl fluoro-arenes can well couple to afford thioethers in high yields. The reaction is believed to proceed by oxidative addition and reductive elimination.