33681-23-1

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Chloro-1-(2,6-dimethyl-piperidin-1-yl)-ethanone is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a valuable building block for the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Organic Compound Synthesis:
In addition to its pharmaceutical applications, 2-Chloro-1-(2,6-dimethyl-piperidin-1-yl)-ethanone is also employed in the synthesis of other organic compounds. Its versatility in chemical reactions makes it a useful component in the creation of a wide range of organic molecules.
Used in Research and Development:
2-Chloro-1-(2,6-dimethyl-piperidin-1-yl)-ethanone plays a role in research and development within the chemical and pharmaceutical industries. It is utilized in the exploration of new chemical reactions, the development of novel synthetic pathways, and the study of its properties to enhance understanding and application in various fields.
Used in Chemical Industry:
2-Chloro-1-(2,6-dimethyl-piperidin-1-yl)-ethanone is used in the chemical industry for the production of various chemical products. Its unique properties make it suitable for a range of applications, from the synthesis of specialty chemicals to the development of new materials with specific properties.

InChI:InChI=1/C9H16ClNO/c1-7-4-3-5-8(2)11(7)9(12)6-10/h7-8H,3-6H2,1-2H3

Upstream product

• 79-04-9 chloroacetyl chloride 
• 504-03-0 2.6-dimethylpiperidine 

Downstream Products

• 179021-63-7 2,6-dimethyl-1-[[4-(phenylmethyl)phenoxy]acetyl]piperidine 

Relevant academic research and scientific papers

Synthesis and anticancer potential of novel xanthone derivatives with 3,6-substituted chains

In an effort to develop new drug candidates with enhanced anticancer activity, our team synthesized and assessed the cytotoxicity of a series of novel xanthone derivatives with two longer 3,6-disubstituted amine carbonyl methoxy side chains on either benzene ring in selected human cancer cell lines. An MTT assay revealed that a set of compounds with lower IC50values than the positive control, 5-FU, exhibited greater anticancer effects. The most potent derivative (XD8) exhibited anticancer activity in MDA-MB-231, PC-3, A549, AsPC-1, and HCT116 cells lines with IC50values of 8.06, 6.18, 4.59, 4.76, and 6.09?μM, respectively. Cell cycle analysis and apoptosis activation suggested that the mechanism of action of these derivatives includes cell cycle regulation and apoptosis induction.

Synthesis, spectral studies and anti-inflammatory activity of glycolamide esters of niflumic acid as potential prodrugs

In order to reduce the gastric irritation caused by direct contract mechanism of the carboxylic acid group, a series of glycolamide esters of niflumic (CAS 4394-00-7) (1) have been prepared as biolabile prodrugs by reacting appropriate 2-chloroacetamides with niflumic acid. The required 2-chloroacetamides were obtained by the condensation of chloroacetyl chloride and corresponding amine. Their structures were confirmed by UV, IR and 1H NMR spectra. Selected compounds were evaluated for anti-inflammatory activity in carrageenan induced paw oedema in rats at the doses of 45, 90 and 150 mg/kg b.w. Prodrugs showed comparable anti-inflammatory activity (67.1-79.4%) at 150 mg/kg b.w. with respect to niflumic acid (70.3%) at 45 mg/kg b.w., indicating moderate release of niflumic acid in vivo. The highest activity was observed with diethylamine (4) and pyrrolidine (9) derivatives.

LTA4 HYDROLASE INHIBITOR PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE

The present invention provides compounds of the formula Ar1-Q-Ar2-Y-R-Z and pharmaceutically acceptable salts thereof wherein Ar1 and Ar2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an a

BENZOTHIAZEPINE AND BENZOXAZEPINE DERIVATIVES AS CHOLECYSTOKININ RECEPTOR ANTAGONISTS

The present invention relates to novel substituted benzothiazepines and benzoxazepines of the formula STR1 wherein R 1, R 2, R. sup. 7, R 8, R 9 and X are as defined below, and to novel intermediates used in the synthesis of such compounds. Such compounds are useful in the treatment and prevention of gastrointestinal disorders, pain and anxiety disorders.

LTA4 HYDROLASE INHIBITORS

The present invention provides compounds of the formula Ar1?Q?Ar2?Y?R?Z and pharmaceutically acceptable salts thereof wherein Ar1 and Ar2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an a

Amide phosphorothiolate herbicides

The present invention relates to new herbicidal phosphorothioate (phosphorodithioate) derivatives and to preparation thereof.