336877-75-9

Basic information

• Product Name: H-D-Phg(4-NO2)-OH
• Synonyms: D-4-Nitrophenylglycine; (R)-2-Amino-2-(4-nitrophenyl)acetic acid
• CAS NO: 336877-75-9
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.16000
• Mol File: 336877-75-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: H-D-Phg(4-NO2)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-Phg(4-NO2)-OH(336877-75-9)
• EPA Substance Registry System: H-D-Phg(4-NO2)-OH(336877-75-9)

Safety Data

• Hazardous Substances Data: 336877-75-9(Hazardous Substances Data)

Usage

General Description

H-D-Phg(4-NO2)-OH is a chemical compound composed of a 4-nitrophenylglycine (Phg) amino acid derivative. The "H-D" in its name indicates that it is a dipeptide, meaning it is composed of two amino acids linked together. The 4-NO2 in its name denotes the presence of a 4-nitro substituent on the phenyl ring of the glycine molecule. This chemical may have potential applications in pharmaceuticals, biochemistry, or materials science due to its unique structure and properties. It could also be used in research and development of peptide-based drugs or as a building block for the synthesis of more complex molecules.

Upstream product

• 5407-25-0 2-amino-2-(4-nitrophenyl)acetic acid 
• 24113-00-6 4-N-acetylnitrophenylglycine 
• 856214-71-6 4-nitro-N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)benzylideneamine 
• 555-16-8 4-nitrobenzaldehdye 
• 56-40-6 glycine 
• 875-74-1 (R)-phenylglycine 

Downstream Products

• 40512-41-2 D-N-(tert-butoxycarbonyl)-4-nitrophenylglycine 

Relevant articles and documents

Studies on enantioselective liquid-liquid extraction of amino-(4-nitro-phenyl)-acetic acid enantiomers: Modeling and optimization

BINAP-metal complexes were prepared as extractant for enantioselective liquid-liquid extraction (ELLE) of amino-(4-nitro-phenyl)-acetic acid (NPA) enantiomers. The influence of process variables, including types of organic solvents and metal precursor, co

Substituted hydantoins

The present invention relates to compounds of the formula methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.

Synthesis of α-Amino Acids via Asymmetric Phase Transfer-Catalyzed Alkylation of Achiral Nickel(II) Complexes of Glycine-Derived Schiff Bases

Achiral, diamagnetic Ni(II) complexes 1 and 3 have been synthesized from Ni(II) salts and the Schiff bases, generated from glycine and PBP (7) and PBA (11), respectively, in MeONa/MeOH solutions. The requisite carbonyl-derivatizing agents pyridine-2-carboxylic acid(2-benzoyl-phenyl)-amide 7 (PBP) and pyridine-2-carboxylic acid(2-formyl-phenyl)-amide 11 (PBA) were readily prepared from picolinic acid and o-aminobenzophenone or picolinic acid and methyl o-anthranilate, respectively. The structure of 1 was established by X-ray crystallography. Complexes 1 and 3 were found to undergo C-alkylation with alkyl halides under PTC conditions in the presence of β-naphthol or benzyltriethylammonium bromide as catalysts to give mono- and bis-alkylated products, respectively. Decomposition of the complexes with aqueous HCI under mild conditions gave the required amino acids, and PBP and PBA were recovered. Alkylation of 1 with highly reactive alkyl halides, carried out under the PTC conditions in the presence of 10% mol of (S)- or (R)-2-hydroxy-2′ -amino-1,1′-binaphthyl 31a (NOBIN) and/or its N-acyl derivatives and by (S)- or (R)-2-hydroxy-8′-amino-1,1′-binaphthyl 32a (iso-NOBIN) and its N-acyl derivatives, respectively, gave rise to α-amino acids with high enantioselectivities (90-98.5% ee) in good-to-excellent chemical yields at room temperature within several minutes. An unusually large positive nonlinear effect was observed in these reactions. The Michael addition of acrylic derivatives 37 to 1 was conducted under similar conditions with up to 96% ee. The 1H NMR and IR spectra of a mixture of the sodium salt of NOBIN and 1 indicated formation of a complex between the two components. Implications of the association and self-association of NOBIN for the observed sense of asymmetric induction and nonlinear effects are discussed.