336877-75-9

Usage

Uses

Used in Pharmaceutical Industry:
H-D-Phg(4-NO2)-OH is used as a potential pharmaceutical candidate for the development of peptide-based drugs due to its unique structure and properties. Its dipeptide nature and 4-nitro substituent may contribute to its therapeutic effects and potential applications in treating various diseases.
Used in Biochemistry Research:
H-D-Phg(4-NO2)-OH is used as a research tool in biochemistry to study the interactions between amino acids, peptides, and other biomolecules. Its unique structure allows researchers to investigate the effects of specific modifications on the properties and functions of peptides, providing insights into the design of novel bioactive compounds.
Used in Materials Science:
H-D-Phg(4-NO2)-OH is used as a building block in materials science for the synthesis of more complex molecules and the development of new materials with specific properties. Its dipeptide structure and 4-nitro substituent may enable the creation of novel materials with applications in various industries, such as medicine, agriculture, or environmental science.
Used in Drug Development:
H-D-Phg(4-NO2)-OH is used in the research and development of new drugs, particularly peptide-based therapeutics. Its unique structure and properties may offer advantages in terms of bioavailability, target specificity, and reduced side effects compared to traditional small molecule drugs. H-D-Phg(4-NO2)-OH can be further modified or combined with other molecules to enhance its therapeutic potential and address unmet medical needs.

Upstream product

• 875-74-1 (R)-phenylglycine 
• 24113-00-6 4-N-acetylnitrophenylglycine 
• 5407-25-0 2-amino-2-(4-nitrophenyl)acetic acid 
• 856214-71-6 4-nitro-N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)benzylideneamine 
• 555-16-8 4-nitrobenzaldehdye 
• 56-40-6 glycine 

Downstream Products

• 40512-41-2 D-N-(tert-butoxycarbonyl)-4-nitrophenylglycine 

Relevant academic research and scientific papers

Studies on enantioselective liquid-liquid extraction of amino-(4-nitro-phenyl)-acetic acid enantiomers: Modeling and optimization

BINAP-metal complexes were prepared as extractant for enantioselective liquid-liquid extraction (ELLE) of amino-(4-nitro-phenyl)-acetic acid (NPA) enantiomers. The influence of process variables, including types of organic solvents and metal precursor, co

METHOD FOR INHIBITING PROLIFERATION OF TUMOR CELLS

Disclosed are methods for synergistically inhibiting the proliferation of tumor cells by contacting the tumor cells with a MEK inhibitor compound and erlotinib, either sequentially or simultaneously. Also disclosed are methods for inhibiting the proliferation of tumor cells in a human, by administering to the human, sequentially or simultaneously, an amount of erlotinib and a MEK inhibitor compound, wherein the amounts are effective, in combination, to synergistically inhibit the proliferation of the tumor cells in the human.

Substituted hydantoins

The present invention relates to compounds of the formula methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.

Synthesis of α-Amino Acids via Asymmetric Phase Transfer-Catalyzed Alkylation of Achiral Nickel(II) Complexes of Glycine-Derived Schiff Bases

Achiral, diamagnetic Ni(II) complexes 1 and 3 have been synthesized from Ni(II) salts and the Schiff bases, generated from glycine and PBP (7) and PBA (11), respectively, in MeONa/MeOH solutions. The requisite carbonyl-derivatizing agents pyridine-2-carboxylic acid(2-benzoyl-phenyl)-amide 7 (PBP) and pyridine-2-carboxylic acid(2-formyl-phenyl)-amide 11 (PBA) were readily prepared from picolinic acid and o-aminobenzophenone or picolinic acid and methyl o-anthranilate, respectively. The structure of 1 was established by X-ray crystallography. Complexes 1 and 3 were found to undergo C-alkylation with alkyl halides under PTC conditions in the presence of β-naphthol or benzyltriethylammonium bromide as catalysts to give mono- and bis-alkylated products, respectively. Decomposition of the complexes with aqueous HCI under mild conditions gave the required amino acids, and PBP and PBA were recovered. Alkylation of 1 with highly reactive alkyl halides, carried out under the PTC conditions in the presence of 10% mol of (S)- or (R)-2-hydroxy-2′ -amino-1,1′-binaphthyl 31a (NOBIN) and/or its N-acyl derivatives and by (S)- or (R)-2-hydroxy-8′-amino-1,1′-binaphthyl 32a (iso-NOBIN) and its N-acyl derivatives, respectively, gave rise to α-amino acids with high enantioselectivities (90-98.5% ee) in good-to-excellent chemical yields at room temperature within several minutes. An unusually large positive nonlinear effect was observed in these reactions. The Michael addition of acrylic derivatives 37 to 1 was conducted under similar conditions with up to 96% ee. The 1H NMR and IR spectra of a mixture of the sodium salt of NOBIN and 1 indicated formation of a complex between the two components. Implications of the association and self-association of NOBIN for the observed sense of asymmetric induction and nonlinear effects are discussed.

New proctolin analogues modified by the novel D-or L-phenylglycine derivatives. Synthesis and biological studies

New analogues of insect neuromodulator proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH), modified in position 2 of the peptide chain by L-or D-phenylglycine and its 4-substituted derivatives were synthesized. For modification of proctolin a series of novel L-or D-phenylglycine derivatives H-Phg(4-NO2)-OH (1), Boc-Phg(4-NO2)-OH (2), Boc-Phg(4-Me2N)-OH (3), H-Phg(4-OBzl)-OH (4), Boc-Phg(4-OBzl)-OH (5), H-D-Phg(4-NO2)-OH (6), Boc-D-Phg(4-NO2,)-OH (7), Boc-D-Phg(4-Me2N)-OH (8), were used. The following proctolin analogues were synthesized: H-Arg-Phg-Leu-Pro-Thr-OH (9), H-Arg-D-Phg-Leu-Pro-Thr-OH (10), H-Arg-Phg(4-OH)-Leu-Pro-Thr-OH (11), H-Arg-D-Phg(4-OH)-Leu-Pro-Thr-OH (12), H-Arg-Phg(4-NO2)-Leu-Pro-Thr-OH (13), H-Arg-D-Phg(4-NO2)-Leu-Pro-Thr-OH (14), H-Arg-Phg(4-NH2)-Leu-Pro-Thr-OH (15), H-Arg-D-Phg(4-NH2)-Leu-Pro-Thr-OH (16), H-Arg-Phg(4-NMe2)-Leu-Pro-Thr-OH (17), H-Arg-D-Phg(4-NMe2)-Leu-Pro-Thr-OH (18). Myotropic activity of proctolin analogues 9-18 was assayed in vitro on the semi-isolated heart of the mealworm Tenebrio molitor and on the foregut of the locust Schistocerca gregaria. All analogues showed a weak or none activity.