33691-09-7

Usage

Uses

Used in Organic Chemistry:
Benzeneacetic acid, 4-chloro-.alpha.-formyl-, ethyl ester is used as a reagent for facilitating various chemical reactions in the field of organic chemistry. Its unique structure allows it to participate in a wide range of reactions, making it a valuable component in the synthesis of different compounds.
Used in Chemical Synthesis:
In the chemical synthesis industry, Benzeneacetic acid, 4-chloro-.alpha.-formyl-, ethyl ester is used as an intermediate in the production of more complex molecules. Its reactivity and structural features make it a key component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Development:
Benzeneacetic acid, 4-chloro-.alpha.-formyl-, ethyl ester is used as a building block in the development of new pharmaceutical compounds. Its versatility in participating in various chemical reactions enables the creation of novel drug candidates with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, Benzeneacetic acid, 4-chloro-.alpha.-formyl-, ethyl ester is used as a precursor in the synthesis of pesticides and other crop protection agents. Its role in the production process contributes to the development of effective and environmentally friendly agrochemicals.
Used in Specialty Chemicals:
Benzeneacetic acid, 4-chloro-.alpha.-formyl-, ethyl ester is used as a key component in the production of specialty chemicals, such as dyes, fragrances, and flavorings. Its reactivity and structural properties make it an essential ingredient in the formulation of these high-value products.

Upstream product

• 14062-24-9 4-chloro-benzeneacetic acid, ethyl ester 
• 109-94-4 formic acid ethyl ester 
• 7476-81-5 p-chlorophenyl butanoate 
• 1878-66-6 4-chlorophenylacetic Acid 

Downstream Products

• 15937-29-8 3-ethoxy-2-(4-chloro-phenyl)-acrylic acid ethyl ester 
• 104920-82-3 7-amino-3-(4-chlorophenyl)-2-hydroxy-1,8-naphthyridine 
• 607714-56-7 3-[(E)-Benzyloxyimino]-2-(4-chloro-phenyl)-propionic acid ethyl ester 
• 91632-27-8 4-(4-Chloro-phenyl)-2H-isoxazol-5-one 
• 104920-90-3 8-amino-4-(4-chlorophenyl)tetrazolo<1,5-a><1,8>naphthyridine 
• 104920-93-6 8-hydroxy-4-(4-chlorophenyl)tetrazolo<1,5-a><1,8>naphthyridine 
• 104920-84-5 7-acetamido-2-chloro-3-(4-chlorophenyl)-1,8-naphthyridine 
• 104920-87-8 8-acetamido-4-(4-chlorophenyl)tetrazolo<1,5-a><1,8>naphthyridine 
• 1078133-75-1 C₂₄H₂₀Br₂ClNO₃ 
• 1078133-65-9 C₂₄H₂₀Br₂ClNO₃ 
• 1078133-90-0 C₂₀H₂₀ClNO₂ 
• 1078133-79-5 C₁₇H₁₅ClFNO₂ 
• 1078133-69-3 C₁₇H₁₅ClFNO₂ 
• 1078133-82-0 C₁₇H₁₄Br₂ClNO₂ 

Relevant academic research and scientific papers

PROCESSES FOR THE PREPARATION OF PYRIMIDINYLCYCLOPENTANE COMPOUNDS

The present invention relates to a process for the preparation of a compound of formula (I), wherein R1 is as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.

An efficient catalytic asymmetric synthesis of a β2-amino acid on multikilogram scale

We describe herein a scalable catalytic asymmetric hydrogenation process for the multikilogram-scale production of a β 2-amino acid. A short and efficient synthesis of the starting unsaturated N-Boc-protected β 2-enamide was developed followed by extensive catalysis screening and optimization studies that identified a simple Ru-BINAP catalyst system to directly afford the (S) product in high enantiomeric excess and yield. The final process enabled the multikilogram production in >99% ee, to be used as a key component for one of our clinical candidates.

Lewis base catalyzed asymmetric hydrosilylation of α-substituted β-enamino esters: Facile access to enantioenriched β2-amino esters via dynamic kinetic resolution

A chiral Lewis base organocatalyzed asymmetric hydrosilylation of α-substituted β-enamino esters is presented. The reactions proceeded through dynamic kinetic resolution to afford various enantioenriched β2-amino esters with high yields (up to

PROCESS FOR MAKING AMINO ACID COMPOUNDS

The invention provides new processes for making and purifying amino acid compounds, which are useful in the preparation of AKT inhibitors used in the treatment of diseases such as cancer, including the compound (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.

Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials

A series of potential antimicrobial derivatives possessing bioisosteric replacements for the central oxazolidinone ring found in oxazolidinone antibacterials have been prepared. The design concept involved replacement of the requisite sp3-hybridized stereogenic center found at the 5-position of the oxazolidinone with a nitrogen atom. The synthesis and antibacterial activity of three such ring systems, the benzisoxazolinones, pyrroles, and isoxazolinones is described.

Structure-activity relationships of the peptide deformylase inhibitor BB-3497: Modification of the methylene spacer and the P1′ side chain

Structural modifications to the peptide deformylase inhibitor BB-3497 are described. In this paper, we describe the initial SAR around this lead for modifications to the methylene spacer and the P1′ side chain. Enzyme inhibition and antibacterial activity data revealed that the optimum distance between the N-formyl hydroxylamine metal binding group and the P1′ side chain is one unsubstituted methylene unit. Additionally, lipophilic P1′ side chains that closely mimic the methionine residue in the substrate provided compounds with the best microbiological profile.

Pyrimidin-4-one derivatives, their intermediates for their production and processes for producing these compounds

PCT No. PCT/JP96/02169 Sec. 371 Date Feb. 10, 1998 Sec. 102(e) Date Feb. 10, 1998 PCT Filed Aug. 1, 1996 PCT Pub. No. WO97/06150 PCT Pub. Date Feb. 20, 1997Novel pyrimidin-4-one derivatives of formula [1] are provided, which are useful as active ingredien

1(2H)-Isoquinolone compounds and acid addition salts thereof

1(2H)-Isoquinolone compounds represented by the formula (1) STR1 wherein Y represents hydrogen, chlorine or a methoxy group, Z represents a straight chain or branched chain divalent saturated aliphatic hydrocarbon group having 2 to 4 carbon atoms, R1