33691-67-7Relevant academic research and scientific papers
SYNTHESIS OF TRI-SUBSTITUTED FURANS: MILD Ti(IV)-MEDIATED COUPLINGS TO ACETALS. CONSTRUCTION OF THE EPOXY HEMI-AMIDO KETAL OF FUSARIN C
Williams, Robert M.,Esslinger, Christopher S.
, p. 3635 - 3638 (1991)
Coupling of β-keto amides and β-keto esters to 2-alkoxy methyl furanosides with TiCl4 directly furnishes tri-substituted furans.The epoxy hemi-amido ketal ring system of fusarin C is constructed in two steps using this methodology.
HETEROCYCLIC AMIDES AS ROCK INHIBITORS
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Page/Page column 79, (2011/10/03)
The present invention relates to new kinase inhibitors of formula (I), more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.
Intramolecular vinylsilane-oxocarbenium condensations: Concise assembly of cis-bicyclic ether arrays
Fearnley, Stephen Philip,Lory, Pedro
, p. 3507 - 3510 (2008/02/12)
Lewis acid-mediated intramolecular attack of vinylsilanes at tethered oxonium precursors 1 results in a rapid assembly of the cis-fused bicyclic ether species 3, with complete regio- and stereospecific control, and in some cases near-quantitative yield. C
Substrate Specificity and Carbohydrate Synthesis Using Transketolase
Kobori, Yoshihiro,Myles, David C.,Whitesides, George M.
, p. 5899 - 5907 (2007/10/02)
This paper describes the use of the enzyme transketolase as a catalyst in organic synthesis.The properties of transketolase from both yeast and spinach were investigated.The yeast enzyme was found to be more convenient for routine use.Examination of the substrate specificity of yeast tansketolase demonstrated that the enzyme accepts a wide variety of 2-hydroxy aldehydes as substrates.A practical protocol for tansketolase-catalyzed condensation of hydroxypyruvic acid with these aldehydes has been developed and used for the synthesis of four carbohydrates: L-idose, L-gulose, 2-deoxy-L-xylohexose, and L-xylose.
