337-33-7

Basic information

• Product Name: 2,2,3,3,3-PENTAFLUORO-1,1-(DIPHENYL)PROPANE-1-OL
• Synonyms: 2,2,3,3,3-PENTAFLUORO-1,1-DIPHENYLPROPAN-1-OL;2,2,3,3,3-PENTAFLUORO-1,1-(DIPHENYL)PROPANE-1-OL;alpha-(Pentafluoroethyl)benzhydrol
• CAS NO: 337-33-7
• Molecular Formula: C₁₅H₁₁F₅O
• Molecular Weight: 302.24
• Mol File: 337-33-7.mol
• Article Data: 17

Chemical Properties

• Melting Point: 84°C
• Boiling Point: 351.2°Cat760mmHg
• Flash Point: 166.2°C
• Appearance: /
• Density: 1.328g/cm³
• Vapor Pressure: 1.55E-05mmHg at 25°C
• Refractive Index: 1.497
• CAS DataBase Reference: 2,2,3,3,3-PENTAFLUORO-1,1-(DIPHENYL)PROPANE-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,3,3,3-PENTAFLUORO-1,1-(DIPHENYL)PROPANE-1-OL(337-33-7)
• EPA Substance Registry System: 2,2,3,3,3-PENTAFLUORO-1,1-(DIPHENYL)PROPANE-1-OL(337-33-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 337-33-7(Hazardous Substances Data)

Usage

General Description

2,2,3,3,3-PENTAFLUORO-1,1-(DIPHENYL)PROPANE-1-OL is a fluorinated alcohol compound, consisting of a propyl backbone with five fluorine atoms and two phenyl groups attached. It is commonly used as a synthetic intermediate in the production of pharmaceuticals, agrochemicals, and specialty chemicals due to its unique molecular structure and properties. 2,2,3,3,3-PENTAFLUORO-1,1-(DIPHENYL)PROPANE-1-OL has strong electron-withdrawing properties, making it useful for various chemical reactions and organic synthesis. It also has potential applications in material science and as a building block for designing new compounds with specific properties. Additionally, it is important for researchers to understand the potential health and environmental effects of 2,2,3,3,3-PENTAFLUORO-1,1-(DIPHENYL)PROPANE-1-OL, as fluorinated compounds can have unique toxicological properties and environmental persistence.

InChI:InChI=1/C15H11F5O/c16-14(17,15(18,19)20)13(21,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,21H

Upstream product

• 378-75-6 perfluoropropionic acid methyl ester 
• 591-51-5 phenyllithium 
• 119-61-9 benzophenone 
• 354-64-3 Pentafluoroethyl iodide 
• 676-58-4 methylmagnesium chloride 
• 109-72-8 n-butyllithium 
• 354-33-6 1,1,1,2,2-pentafluoroethane 
• 867212-85-9 C₉H₉F₁₅NPSi 
• 58431-32-6 tris(pentafluoroethyl)phosphine oxide 
• 854992-65-7 C₁₇H₁₀F₈O 
• 1623-05-8 perfluoro(propyl vinyl ether) 
• 426-65-3 ethyl Pentafluoropropionate 

Downstream Products

• 340-10-3 1,1,1,2,2-pentafluoro-3,3-diphenyl-propane 

Relevant articles and documents

On Pentakis(pentafluoroethyl)stannate, [Sn(C2F5)5]?, and the Gas-Free Generation of Pentafluoroethyllithium, LiC2F5

Pentafluoroethyllithium, LiC2F5, has been established as an efficient and versatile reagent for the transfer of the pentafluoroethyl unit to a number of electrophiles. Here, the stability of this species up to ?40 °C is of advantage, particularly in comparison to its smaller congener LiCF3. The usual production of LiC2F5, however, from gaseous HC2F5 or IC2F5 and strong bases requires specially designed apparatuses, which severely impeded its value as a laboratory reagent. In this contribution we communicate an alternative gas-free and highly efficient protocol for the synthesis of LiC2F5 from the already commercialized stannate salt [PPh4][Sn(C2F5)5]. The [Sn(C2F5)5]? anion represents not only the first example of a structurally characterized hypervalent pentaalkylstannate but also serves as a precursor for the synthesis of the homoleptic tetrakis(pentafluoroethyl)stannane, Sn(C2F5)4. The reaction of the latter with n-butyllithium provides an insight into the mechanism of LiC2F5 generation.

Pentafluoroethylation of Carbonyl Compounds by HFC-125 via the Encapsulation of the K Cation with Glymes

A simple protocol to overcome the explosive pentafluoroethylation of carbonyl compounds by HFC-125 is described. The use of potassium (K) bases with triglyme or tetraglyme as a solvent safely yields the pentafluoroethylation products in good to high yield

NOVEL METHOD FOR PRODUCING PERFLUOROALKYLATING AGENTS USING MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL, AND METHOD FOR PRODUCING AROMATIC PERFLUOROALKYL COMPOUND USING THE SAME

PROBLEM TO BE SOLVED: To provide a simple method for producing trifluoromethyltriol borate potassium from trifluoromethane. SOLUTION: There is provided a method for producing a compound represented by the formula [7], comprising: reacting a monohydroperfluoroalkane with a base and trialkyl borate in an organic solvent; and then reacting the reaction solution with triol. [In the formula, RF is an alkyl group such as a linear chain of C1-2, and a perfluoroalkyl group in which all H on C is substituted with F; R6 is H or a C1-2 linear alkyl group, or the like; M may be a metal or the like belonging to Group I, Group II, Group III, Group IV, Group V, Group VI, Group VII, Group VIII, Group IX, Group X, Group XI, Group XII, and Group XIII in the periodic table of elements, and they may be a single substance or a mixture of a plurality of substances and y corresponds to the oxidation number of the substance represented by M.] SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT