337-33-7

Usage

Uses

Used in Pharmaceutical Industry:
2,2,3,3,3-PENTAFLUORO-1,1-(DIPHENYL)PROPANE-1-OL is used as a synthetic intermediate for the production of pharmaceuticals, leveraging its unique molecular structure to facilitate the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2,2,3,3,3-PENTAFLUORO-1,1-(DIPHENYL)PROPANE-1-OL serves as a key intermediate in the synthesis of agrochemicals, contributing to the creation of effective compounds for crop protection and enhancement of agricultural yields.
Used in Specialty Chemicals Production:
2,2,3,3,3-PENTAFLUORO-1,1-(DIPHENYL)PROPANE-1-OL is utilized as a building block in the synthesis of specialty chemicals, where its electron-withdrawing properties are harnessed to design compounds with tailored characteristics for specific applications.
Used in Material Science:
This fluorinated alcohol compound is also applied in material science, where its unique properties can be employed to develop new materials with distinct characteristics, potentially useful in various high-tech applications.
Used in Organic Synthesis:
Due to its strong electron-withdrawing properties, 2,2,3,3,3-PENTAFLUORO-1,1-(DIPHENYL)PROPANE-1-OL is used in organic synthesis to facilitate various chemical reactions, enabling the creation of a wide range of organic compounds.
It is crucial for researchers to consider the potential health and environmental impacts of 2,2,3,3,3-PENTAFLUORO-1,1-(DIPHENYL)PROPANE-1-OL, as fluorinated compounds may exhibit unique toxicological profiles and environmental persistence, necessitating careful assessment and management in their application and disposal.

InChI:InChI=1/C15H11F5O/c16-14(17,15(18,19)20)13(21,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,21H

Upstream product

• 426-65-3 ethyl Pentafluoropropionate 
• 378-75-6 perfluoropropionic acid methyl ester 
• 591-51-5 phenyllithium 
• 1623-05-8 perfluoro(propyl vinyl ether) 
• 854992-65-7 C₁₇H₁₀F₈O 
• 119-61-9 benzophenone 
• 354-64-3 Pentafluoroethyl iodide 
• 58431-32-6 tris(pentafluoroethyl)phosphine oxide 
• 867212-85-9 C₉H₉F₁₅NPSi 
• 676-58-4 methylmagnesium chloride 
• 109-72-8 n-butyllithium 
• 354-33-6 1,1,1,2,2-pentafluoroethane 

Downstream Products

• 340-10-3 1,1,1,2,2-pentafluoro-3,3-diphenyl-propane 

Relevant academic research and scientific papers

On Pentakis(pentafluoroethyl)stannate, [Sn(C2F5)5]?, and the Gas-Free Generation of Pentafluoroethyllithium, LiC2F5

Pentafluoroethyllithium, LiC2F5, has been established as an efficient and versatile reagent for the transfer of the pentafluoroethyl unit to a number of electrophiles. Here, the stability of this species up to ?40 °C is of advantage, particularly in comparison to its smaller congener LiCF3. The usual production of LiC2F5, however, from gaseous HC2F5 or IC2F5 and strong bases requires specially designed apparatuses, which severely impeded its value as a laboratory reagent. In this contribution we communicate an alternative gas-free and highly efficient protocol for the synthesis of LiC2F5 from the already commercialized stannate salt [PPh4][Sn(C2F5)5]. The [Sn(C2F5)5]? anion represents not only the first example of a structurally characterized hypervalent pentaalkylstannate but also serves as a precursor for the synthesis of the homoleptic tetrakis(pentafluoroethyl)stannane, Sn(C2F5)4. The reaction of the latter with n-butyllithium provides an insight into the mechanism of LiC2F5 generation.

NOVEL METHOD FOR PRODUCING PERFLUOROALKYLATING AGENTS USING MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL, AND METHOD FOR PRODUCING AROMATIC PERFLUOROALKYL COMPOUND USING THE SAME

PROBLEM TO BE SOLVED: To provide a simple method for producing trifluoromethyltriol borate potassium from trifluoromethane. SOLUTION: There is provided a method for producing a compound represented by the formula [7], comprising: reacting a monohydroperfluoroalkane with a base and trialkyl borate in an organic solvent; and then reacting the reaction solution with triol. [In the formula, RF is an alkyl group such as a linear chain of C1-2, and a perfluoroalkyl group in which all H on C is substituted with F; R6 is H or a C1-2 linear alkyl group, or the like; M may be a metal or the like belonging to Group I, Group II, Group III, Group IV, Group V, Group VI, Group VII, Group VIII, Group IX, Group X, Group XI, Group XII, and Group XIII in the periodic table of elements, and they may be a single substance or a mixture of a plurality of substances and y corresponds to the oxidation number of the substance represented by M.] SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

NOVEL METHOD FOR PRODUCING PERFLUOROALKYLATING AGENTS USING MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL, AND METHOD FOR PRODUCING AROMATIC PERFLUOROALKYL COMPOUND USING THE SAME

PROBLEM TO BE SOLVED: To provide a method for producing an aromatic perfluoroalkyl compound using silylated trifluoromethyl carbinol. SOLUTION: There is provided a method for producing an aromatic perfluoroalkyl compound represented by the general formula [10], in which a compound represented by the formula [9] and a compound represented by the formula [1] are reacted in an organic solvent in the presence of a copper catalyst, a nitrogen ligand and a metal fluoride. R7-X...[9], RF-R7...[10] [In the formula, R7 is an aryl group or the like which may have a substituent; X is F, Cl, Br or I; RF is an alkyl group such as a linear chain of C1-2, and a perfluoroalkyl group in which all H on C is substituted with F; R1 and R2 are each independently H or a C1-2 linear alkyl group, or the like; R1 and R2 may be integrated to form a ring; and R3, R4 and R5 are each independently H or a C1-2 linear alkyl group, or the like.] SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

NOVEL METHOD FOR PRODUCING PERFLUOROALKYLATING AGENTS USING MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL, AND METHOD FOR PRODUCING AROMATIC PERFLUOROALKYL COMPOUNDS USING THE SAME

To provide a simple method for producing silylated trifluoromethylcarbinol from trifluoromethane.SOLUTION: There is provided a method for producing a compound represented by the formula [1], in which the compound is obtained by reacting a monohydroperfluoroalkane, a carbonyl compound, and NaH in an organic solvent and then reacting the reaction solution with a silylating agent. [In the formula, RF is an alkyl group such as a linear chain of C1 to 2, and a perfluoroalkyl group in which all H on C is substituted with F; R1 and R2 are independently alkyl groups such as a linear chain of H or C1 to 2, or the like respectively; R1 and R2 may be integrated to form a ring; and R3, R4 and R5 are independently H or C1 to 2 linear alkyl groups, or the like respectively.]SELECTED DRAWING: None

Pentafluoroethylation of Carbonyl Compounds Using HFC-125 in a Flow Microreactor System

The protocol of micro-flow nucleophilic pentafluoroethylation using pentafluoroethane (HC2F5, HFC-125), a nontoxic, inexpensive, and commercially available greenhouse gas, is described. The micro-flow pentafluoroethylation by HFC-125 proceeded smoothly at

Pentafluoroethylation of Carbonyl Compounds by HFC-125 via the Encapsulation of the K Cation with Glymes

A simple protocol to overcome the explosive pentafluoroethylation of carbonyl compounds by HFC-125 is described. The use of potassium (K) bases with triglyme or tetraglyme as a solvent safely yields the pentafluoroethylation products in good to high yield

Pentafluoroethyl group containing production of alcohols, organic semiconductor material and intermediate compound of the enzyme activity inhibitor

[A] a pharmaceutical, agrochemical, a pentafluoroethyl group containing alcohol compound useful as a method for producing polymeric functional materials, as well as, organic semiconductor material and enzyme activity inhibitor of the intermediate compound

PREPARATION PROCESS OF PERFLUOROALKYL COMPOUND WITH MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL

A simple production process is provided of a perfluoroalkyl compound that uses monohydroperfluoroalkane as a starting material, the perfluoroalkyl compound being an important intermediate of organic electronic materials, medicine, agricultural chemicals,

NEW MANUFACTURING METHOD OF PERFLUORO ALKYLATING AGENT WHICH USED MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL, AND METHOD FOR MANUFACTURING AROMATIC PERFLUORO ALKYL COMPOUND USING THE SAME

PROBLEM TO BE SOLVED: To provide a method for manufacturing silanized trifluoromethyl carbinol, potassium trifluoromethyl triol borate and an aromatic trifluoromethyl compound from trifluoromethane. SOLUTION: There are provided a method for manufacturing silanized trifluoromethyl carbinol in which trifluoromethyl carbinol obtained by reacting trifluoromethane with a carbonyl compound in the presence of a base is reacted with silanizing agent; or a method for manufacturing potassium trifluoromethyl triol borate in which potassium trifluoromethyl trimethoxy borate obtained by reacting trifluoromethane with trimethoxy borane in the presence of a base is reacted with a triol; and a method for manufacturing an aromatic trifluoromethyl compound obtained by making an aromatic iodide act on silanized trifluoromethyl carbinol or potassium trifluoromethyl triol borate in the presence of catalytic amount of copper (I) iodide and 9,10-phenanthroline. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Electrochemical fluorination (Simons process) - A powerful tool for the preparation of new conducting salts, ionic liquids and strong Br?nsted acids

Electrochemical fluorination (Simons process) provides a cheap commercial access to a series of tris(perfluoroalkyl)diflurophosphoranes. These substances are convenient starting material for the preparation of various fluoro-chemicals. The synthesis of ne