378-75-6

Basic information

• Product Name: Methyl pentafluoropropionate
• Synonyms: PERFLUOROPROPIONIC ACID METHYL ESTER;PENTAFLUOROPROPIONIC ACID METHYL ESTER;2,2,3,3,3-Pentafluoro-propionic acid methyl ester;methylesterkyselinypentafluorpropionove;pentafluoro-propanoicacimethylester;pentafluoro-propionicacimethylester;METHYL PENTAFLUOROPROPIONATE;METHYL PERFLUOROPROPIONATE
• CAS NO: 378-75-6
• Molecular Formula: C₄H₃F₅O₂
• Molecular Weight: 178.06
• EINECS: 206-828-0
• Product Categories: C2 to C5;Carbonyl Compounds;Esters;Halogenated Heterocycles ,Pyrimidines
• Mol File: 378-75-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 61 °C739 mm Hg(lit.)
• Flash Point: 42 °F
• Appearance: clear colorless liquid
• Density: 1.393 g/mL at 25 °C(lit.)
• Vapor Pressure: 8.29mmHg at 25°C
• Refractive Index: n20/D 1.288(lit.)
• Storage Temp.: Flammables area
• BRN: 1777501
• CAS DataBase Reference: Methyl pentafluoropropionate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl pentafluoropropionate(378-75-6)
• EPA Substance Registry System: Methyl pentafluoropropionate(378-75-6)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-37/39
• RIDADR: UN 3272 3/PG 2
• WGK Germany: 2
• RTECS: UF6475500
• TSCA: T
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 378-75-6(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

InChI:InChI=1/C6F10O2/c7-1(17)3(9,10)5(13,14)6(15,16)4(11,12)2(8)18

Upstream product

• 67-56-1 methanol 
• 422-64-0 pentafluoropropionic acid 
• 2544-06-1 3-Methoxypropionic acid 
• 428-59-1 Hexafluoropropene oxide 
• 124008-11-3 Perfluoro<3-(N,N-dimethylamino)propionyl> fluoride 
• 1584-03-8 perfluoro-2-methylpent-2-ene 
• 2070-70-4 perfluoro-4-methyl-2-pentene 
• 422-61-7 perfluoropropanoyl fluoride 
• 100-39-0 benzyl bromide 
• 121-44-8 triethylamine 
• 62949-75-1 4-heptafluoropropoxytrifluoro-1,2-oxathietane 2,2-dioxide 
• 2641-34-1 perfluoro-2,5-dimethyl-3,6-dioxanonanoyl fluoride 
• 116-14-3 polytetrafluoroethylene 
• 1538-06-3 methyl fluoroformate 

Downstream Products

• 337-33-7 1,1-diphenyl-2,2,3,3,3-pentafluoropropan-1-ol 
• 680-14-8 Pentafluorpropionsaeurehydrazid 
• 2145-82-6 2-(pentafluoropropionyl)cyclohexanone 
• 14038-06-3 1-methoxy-4-(pentafluoroethyl)benzene 
• 378-77-8 sodium pentafluoropropionate 
• 354-76-7 2,2,3,3,3-pentafluoropropionamide 
• 131510-28-6 2,2,3,3,3-pentafluoro-1-(4-methoxyphenyl)propan-1-ol 
• 59872-84-3 pentafluoropropionaldehyde Methyl Hemiacetal 
• 422-06-0 2,2,3,3,3-Pentafluoro-propionaldehyde 
• 20825-07-4 1,1,1,5,5,6,6,6-octafluorohexane-2,4-dione 
• 89176-05-6 (E)-4,4,5,5,5-pentafluoro-1-phenylpent-1-en-3-one 
• 52447-16-2 pentafluoroethyl pentafluorophenyl ketone 
• 422-05-9 2,2,3,3,3-pentafluoropropyl alcohol 
• 663-35-4 ethylpentafluoropropionylacetate 

Relevant articles and documents

One stone two birds: Degradation of persistent organic pollutants to a valuable industrial chemical production of pentafluoropropionyl fluoride from HFPO oligomers catalyzed by cesium fluoride in tetraglyme

Hexafluoropropylene oxide (HFPO) oligomers are toxic, bioaccumulative, and persistent organic pollutants (POPs). Consuming the harmful chemicals to prevent them from releasing to nature is of serious significance as far as both natural environments and human health are concerned. In this study, investigation on degradation of HFPO oligomers to pentafluoropropionyl fluoride (PPF), a valuable industrial chemical, is reported. Different combinations of alkali metal fluoride in either diglyme or tetraglyme under both flask and batch autoclave conditions were examined. Under the optimal reaction conditions, HFPO oligomers (n?=?2–10) were completely degraded to PPF in over 90% yield. Reactions on 200?g scale were tested and no deduction of efficiency was observed, which indicates the potential for practical industrial application of this chemistry.

Perfluoroalcohols

Perfluorinated primary alcohol adducts with triethylamine were prepared from lower perfluorinated acid fluorides and triethylamine monohydrofluoride. They are stable compounds and may be used as a source of RFO groups in organic syntheses.