33707-91-4

Basic information

• Product Name: 4-QUINOXALIN-2-YLPHENOL
• Synonyms: 4-QUINOXALIN-2-YLPHENOL;4-(Quinoxalin-2-yl)phenol ,97%;Phenol, 4-(2-quinoxalinyl)-
• CAS NO: 33707-91-4
• Molecular Formula: C₁₄H₁₀N₂O
• Molecular Weight: 222.24
• Mol File: 33707-91-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 204 °C
• Boiling Point: 408.549°C at 760 mmHg
• Flash Point: 200.884°C
• Appearance: /
• Density: 1.279g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.695
• PKA: 8.44±0.15(Predicted)
• CAS DataBase Reference: 4-QUINOXALIN-2-YLPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-QUINOXALIN-2-YLPHENOL(33707-91-4)
• EPA Substance Registry System: 4-QUINOXALIN-2-YLPHENOL(33707-91-4)

Safety Data

• Statements: 22-37/38-41
• Safety Statements: 26-39
• Hazardous Substances Data: 33707-91-4(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C14H10N2O/c17-11-7-5-10(6-8-11)14-9-15-12-3-1-2-4-13(12)16-14/h1-9,17H

Upstream product

• 24645-80-5 (4-hydroxylphenyl)glyoxal 
• 95-54-5 1,2-diamino-benzene 
• 51-67-2 tyrosamine 
• 99233-31-5 1-(4-hydroxyphenyl)-2-iodoethanone 
• 99-93-4 4-Hydroxyacetophenone 
• 2491-38-5 2-bromo-1-(4'-hydroxyphenyl)-1-ethanone 

Downstream Products

• 312272-69-8 acetic acid-(4-quinoxalin-2-yl-phenyl ester) 
• 305858-17-7 benzoic acid-(4-quinoxalin-2-yl-phenyl ester) 
• 5021-46-5 2-(4-methoxyphenyl)quinoxaline 
• 1265637-53-3 3-(4-Methoxy-benzyl)-5-(4-quinoxalin-2-yl-phenoxy)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one 
• 1262801-89-7 3-nitro-4-(quinoxalin-2-yl)phenol 

Relevant articles and documents

Copper-catalyzed aerobic oxidative coupling of o-phenylenediamines with 2-aryl/heteroarylethylamines: direct access to construct quinoxalines

A copper-catalyzed oxidative coupling reaction of o-phenylenediamines with 2-aryl/heteroarylethylamines using molecular oxygen as an oxidant has been developed. This approach provides a practical and direct access to construct quinoxalines in excellent yields at room temperature. The reaction has a broad substrate scope and exhibits excellent functional-group tolerance. This method could be easily scaled up and applied to the synthesis of biologically active molecules bearing a quinoxaline structural scaffold.

Logic design and synthesis of quinoxalines via the integration of iodination/oxidation/cyclization sequences from ketones and 1,2-diamines

A novel protocol for the synthesis of quinoxalines has been developed from simple ketones and 1,2-diamines. This process underwent a logic approach to bis-substituted quinoxalines via a consecutive iodination/Kornblum oxidation/cyclization in the presence of I2/CuO/DMSO and to mono-substituted quinoxalines via an iodination/cyclization/aromatization in the presence of I2/CuO/K3PO4·3H 2O.