99233-31-5

Basic information

• Product Name: Ethanone, 1-(4-hydroxyphenyl)-2-iodo-
• CAS NO: 99233-31-5
• Molecular Formula: C8H7IO2
• Molecular Weight: 262.047
• Mol File: 99233-31-5.mol

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(4-hydroxyphenyl)-2-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-hydroxyphenyl)-2-iodo-(99233-31-5)
• EPA Substance Registry System: Ethanone, 1-(4-hydroxyphenyl)-2-iodo-(99233-31-5)

Safety Data

• Hazardous Substances Data: 99233-31-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(4-hydroxyphenyl)-2-iodois used as a precursor in the synthesis of pharmaceutical drugs. Its unique structure allows for the formation of carbon-carbon and carbon-heteroatom bonds, which are crucial in the development of new drug molecules.
Used in Organic Synthesis:
Ethanone, 1-(4-hydroxyphenyl)-2-iodois used as a reagent in organic synthesis. The presence of the iodine group makes it a valuable intermediate for the formation of complex organic molecules, particularly in the creation of carbon-carbon and carbon-heteroatom bonds, which are essential in the synthesis of a wide range of organic compounds.
Used in Research and Development:
Ethanone, 1-(4-hydroxyphenyl)-2-iodois used as a research compound in the development of new synthetic methods and strategies. Its unique reactivity and properties make it an interesting subject for study, potentially leading to the discovery of novel reactions and applications in various fields of chemistry.

Upstream product

• 2491-38-5 2-bromo-1-(4'-hydroxyphenyl)-1-ethanone 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 156-38-7 4-hydroxyphenylacetate 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 5706-85-4 2-hydroxy-1-(4-hydroxyphenyl)ethan-1-one 
• 1579291-34-1 1-(4-hydroxyphenyl)-2,2-bis(2,4,6-trimethoxyphenyl)ethanone 
• 1579291-25-0 2,2-bis(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)ethanone 
• 1436865-54-1 3-(4-hydroxybenzoyl)indolizine-1-carbonitrile 
• 24645-80-5 (4-hydroxylphenyl)glyoxal 
• 33707-91-4 2-(4-hydroxyphenyl)quinoxaline 
• 57634-55-6 4-(2-aminothiazol-4-yl)phenol 
• 855923-65-8 2-benzylamino-1-(4-hydroxy-phenyl)-ethanone 

Relevant articles and documents

Supramolecular Storage and Controlled Photorelease of an Oxidizing Agent using a Bambusuril Macrocycle

The oxidizing ability of peroxodisulfate upon complexation inside the Bambusuril macrocycle cavity is inhibited. This dianionic agent can be released on demand from its stable 1:1 complex in water (log Ka=6.9 m?1) by addition of a more strongly bound anion, such as iodide (log Ka=7.1 m?1), which can also be delivered in situ upon irradiation from a 4-hydroxyphenacyl iodide derivative with spatial and temporal precision. The oxidizing properties of peroxodisulfate ions liberated from the complex recover and can take part in subsequent chemical transformations.

Direct one-pot synthesis of zolimidine pharmaceutical drug and imidazo[1,2-a]pyridine derivatives via I2/CuO-promoted tandem strategy

An efficient one-pot synthetic protocol was developed for the synthesis of imidazo[1,2-a]pyridines from easily available starting materials: Aromatic ketones, α,β-unsaturated ketones, β-keto esters and 2-aminopyridines. The present reaction proceeded well in MeOH under the media of I2/CuO. By using this method, the marketed drug zolimidine could be prepared easily with 95% yield. All these target products were characterized by NMR, HRMS and IR spectra. Furthermore, the target compound 3fa was determined by X-ray crystallographic analysis.

I2-DMSO catalyzed synthesis of 1,2,2-triarylethanones via dual C-H activation of aryl methyl ketones

An I2-DMSO promoted domino protocol was developed for the synthesis of 1,2,2-triarylethanones from readily available aromatic methyl ketones and methoxybenzenes. The 1,2,2-triarylethanones are important precursors for the synthesis of Tamoxifen

Design and synthesis of 2-acylbenzothiazoles via in situ cross-trapping strategy from benzothiazoles with aryl ketones

An I2/KOH synergistically promoted direct ring-opening aroylation of benzothiazoles with aryl ketones has been discovered. Aryl ketones were seen to act as carbonyl sources to construct 2-acylbenzothiazoles. This reaction could provide an example for the convergent integration of self-labor domino sequences based on an in situ cross-trapping strategy.

A direct method for the synthesis of indolizine derivatives from easily available aromatic ketones, pyridines, and acrylonitrile derivatives

A concise and efficient strategy has been proposed to synthesize indolizine derivatives from easily available aryl or heteroaryl methyl ketones, pyridines, and acrylonitriles. The mechanistic pathway involved the integration of iodination, pyridinium ylid

I2/CuO-catalyzed tandem cyclization strategy for one-pot synthesis of substituted 2-aminothiozole from easily available aromatic ketones/α,β-unsaturated ketones and thiourea

A concise and efficient one-pot process from easily available methyl ketones/unsaturated methyl ketones and thiourea was developed for the synthesis of 2-aminothiazoles under the media of I2/CuO. The method can highly stereoselectivity obtain the E-isomers of 4-ethenyl-2-aminothiazoles (5a-f). All these target molecules were characterized by NMR, HRMS and IR spectra. Furthermore, the target compounds 3c and 5b were further determined by X-ray crystallographic analysis.

Logic design and synthesis of quinoxalines via the integration of iodination/oxidation/cyclization sequences from ketones and 1,2-diamines

A novel protocol for the synthesis of quinoxalines has been developed from simple ketones and 1,2-diamines. This process underwent a logic approach to bis-substituted quinoxalines via a consecutive iodination/Kornblum oxidation/cyclization in the presence of I2/CuO/DMSO and to mono-substituted quinoxalines via an iodination/cyclization/aromatization in the presence of I2/CuO/K3PO4·3H 2O.

Facile synthesis of α-iodo carbonyl compounds and α-iodo dimethyl ketals using molecular iodine and trimethylorthoformate

A novel and direct method for the synthesis of α-iodo ketones and α-iodo dimethyl ketals from acetophenones using iodine and trimethylorthoformate under neutral conditions is described herein.

Highly efficient and clean method for direct α-iodination of aromatic ketones

Under neutral reaction conditions, aromatic ketones were transformed into the corresponding α-iodo ketones in high yields by the combination of copper(II) oxide and iodine. The reaction mechanism showed that copper(II) oxide played multiple roles through random self-sorting. Georg Thieme Verlag Stuttgart.

Metal catalyst-free direct α-iodination of ketones with molecular iodine

Ketones are directly converted to the corresponding α-iodoketones in good yields with molecular iodine under metal catalyst-free conditions. A significant difference in the reactivities was observed for aliphatic and aromatic ketones; whereas aliphatic ke