33708-69-9

Usage

Uses

Used in Pharmaceutical Industry:
BroMo-N-(2-hydroxy-1,1-diMethylethyl)benzaMide is used as an intermediate in the synthesis of positional isomers and analogs of mazindol (M198500) for its potential role as inhibitors of the cocaine binding site of the dopamine transporter site. This application is significant as it may contribute to the development of treatments for cocaine addiction and related disorders by targeting the specific binding sites in the brain responsible for the addictive effects of cocaine.

InChI:InChI=1/C11H14BrNO2/c1-11(2,7-14)13-10(15)8-3-5-9(12)6-4-8/h3-6,14H,7H2,1-2H3,(H,13,15)

Upstream product

• 124-68-5 2-Amino-2-methyl-1-propanol 
• 586-75-4 4-chlorobenzoyl chloride 

Downstream Products

• 51849-98-0 1-[4-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-cycloheptanol 
• 211388-40-8 4-chloro-α-[4-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)phenyl]-benzenemethanol 
• 211388-42-0 4-chloro-α-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-benzenemethanol 

Relevant academic research and scientific papers

NPY ANTAGONISTS, PREPARATION AND USES

The present invention concerns novel compounds, their preparation and their uses, therapeutic uses in particular. More specifically it concerns derivative compounds having at least two aromatic cycles, their preparation and their uses, in particular in the area of human or animal health. These compounds have an affinity for the biological receptors of neuropeptide Y, NPY, present in the central and peripheral nervous systems. The compounds of the invention are preferably NPY antagonists, and more particularly antagonists of sub-type NPY Y1, and can therefore be used for the therapeutic or prophylactic treatment of any disorder involving NPY. The present invention also concerns pharmaceutical compositions containing said compounds, their preparation and their uses, as well as treatment methods using said compounds.

Synthesis of 4-oxazolinephenylboronic acid and heterobiaryl oxazolines via a Suzuki reaction

An efficient synthesis of 4-oxazolinephenylboronic acid from 4-bromobenzoic acid is reported. The title compound couples with heteroaryl halides in presence of Pd(PPh3)4 and Na2CO3 in aqueous toluene to give het

Methods for purifying radiolabelled compounds

One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a fluoroalkyl tin moiety; b) reacting the radiolabelled compound precursor with a radiolabel delivering compound to give a radiolabelled compound, wherein the fluoroalkyl tin moiety is replaced by a radiolabel; and c) eluting the radiolabelled compound from the fluorous polymer.

Positional isomers and analogs of mazindol as potential inhibitors of the cocaine binding site on the dopamine transporter site

A series of compounds, where the keto-tautomeric form of mazindol (2b) was modified by placing the 2-(p-chlorobenzoyl) portion of the molecule in the 3- and 4-positions, substituting the imidazo ring A by a 4,4-dimethyl 1- 2-oxazolo ring, and replacing th

Halogenated protease inhibitors

This invention relates to novel compounds for preventing or retarding the degradation of elastin or other proteins and therefore preventing or retarding the disease states caused by said degradation, of the formula: STR1 or its pharmacologically acceptabl