33709-29-4

Basic information

• Product Name: 1-(3,4,5-trihydroxyphenyl)ethanone
• Synonyms: 1-(3,4,5-trihydroxyphenyl)ethanone;3',4',5'-Trihydroxyacetophenone
• CAS NO: 33709-29-4
• Molecular Formula: C₈H₈O₄
• Molecular Weight: 168.15
• Mol File: 33709-29-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 187–188°C
• Boiling Point: 461.3°Cat760mmHg
• Flash Point: 246.9°C
• Appearance: /
• Density: 1.446g/cm³
• Vapor Pressure: 3.95E-09mmHg at 25°C
• Refractive Index: 1.64
• PKA: 7.85±0.23(Predicted)
• CAS DataBase Reference: 1-(3,4,5-trihydroxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4,5-trihydroxyphenyl)ethanone(33709-29-4)
• EPA Substance Registry System: 1-(3,4,5-trihydroxyphenyl)ethanone(33709-29-4)

Safety Data

• Hazardous Substances Data: 33709-29-4(Hazardous Substances Data)

Usage

Preparation

Preparation by reaction of aluminium chloride on gallacetophenone trimethyl ether in refluxing chlorobenzene (71%).

InChI:InChI=1/C8H8O4/c1-4(9)5-2-6(10)8(12)7(11)3-5/h2-3,10-12H,1H3

Upstream product

• 2887-72-1 1-(3,5-dibromo-4-hydroxyphenyl)ethan-1-one 
• 99-93-4 4-Hydroxyacetophenone 
• 51863-60-6 3,5-dihydroxyacetophenone 
• 2478-38-8 1-(4-hydroxy-3,5-dimethoxy-phenyl)-ethanone 
• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 

Downstream Products

• 896121-38-3 3,4,5-tribenzyloxyphenylmethyl ketone 

Relevant articles and documents

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Intermediates useful for the synthesis of delphinidin chloride

A process is provided for producing delphinidin which comprises reacting a compound of formula STR1 wherein each Pg represents a hydroxyl protecting group, and Lg represents a leaving group with a compound of formula STR2 wherein Pg' represents a hydroxyl protecting group characterized in that the compound of formula VII is produced from an intermediate of formula STR3 wherein each Pg" represents a hydroxyl protecting group and each Alk represents lower alkyl, by (i) subjecting the intermediate of formula IX to hydrolysis and decarboxylation to form 3,4,5-trihydroxyacetophenone of formula STR4 (ii) converting the 3,4,5-trihydroxyacetophenone to the compound of formula VII by introduction of the protecting groups Pg" and converting the group of formula --COCH3 to a group of formula --COCH2 Lg.