33721-54-9

Usage

Uses

Used in Pharmaceutical Synthesis:
N-(2-methoxy-5-nitrophenyl)acetamide is utilized as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows for the development of drugs targeting a range of conditions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, N-(2-methoxy-5-nitrophenyl)acetamide is used for its potential role in the development of drugs for conditions such as cancer, bacterial infections, and inflammation. The presence of the nitro and methoxy groups on the phenyl ring can greatly influence the pharmacological properties of the compounds in which it is incorporated.
Used in Organic Chemistry:
N-(2-methoxy-5-nitrophenyl)acetamide also has potential applications in organic chemistry, particularly for the synthesis of complex molecules. Its versatile structure makes it a valuable building block for creating intricate organic compounds with specific functions and properties.

InChI:InChI=1/C9H10N2O4/c1-6(12)10-8-5-7(11(13)14)3-4-9(8)15-2/h3-5H,1-2H3,(H,10,12)

Upstream product

• 93-26-5 2-methoxyacetanilide 
• 108-24-7 acetic anhydride 
• 99-59-2 3-amino-4-methoxynitrobenzene 
• 74-83-9 methyl bromide 
• 97-60-9 2-acetamido-4-nitrophenol 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 90-04-0 2-methoxy-phenylamine 
• 119-27-7 2,4-dinitroanisole 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 64-19-7 acetic acid 
• 67827-72-9 2-methoxy-5-nitroaniline hydrochloride 

Downstream Products

• 64353-88-4 N-(5-amino-2-methoxyphenyl)-acetamide 
• 66910-71-2 acetic acid-(2-methoxy-4,5-dinitro-anilide) 
• 99-59-2 3-amino-4-methoxynitrobenzene 
• 15854-76-9 2-Methoxy-5-nitro-N-nitroso-acetanilid 
• 20278-59-5 4,5-dinitro-2-methoxyaniline 
• 15854-75-8 2-methoxy-5-nitro-1,1’-biphenyl 
• 79127-57-4 4,5-dihydroxy-4,5-dioxo-1H-pyrrolo{2,3-f}quinoline-2,7,9-tricarboxylic acid 
• 72909-34-3 pyrroloquinoline quinone 
• 953392-39-7 N₁-[5-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-2-(methyloxy)phenyl]-2-methylalaninamide hydrochloride 
• 953391-99-6 1,1-dimethylethyl (2-{[5-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-2-(methyloxy)phenyl]amino}-1,1-dimethyl-2-oxoethyl)carbamate 
• 953391-97-4 N-[5-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-2-(methyloxy)phenyl]acetamide 
• 953391-98-5 N-[3-amino-4-(methyloxy)phenyl]-3-fluoro-4-(5-methyl-2-furanyl)benzenesulfonamide 
• 953391-96-3 N-[5-{[(4-bromo-3-fluorophenyl)sulfonyl]amino}-2-(methyloxy)phenyl]acetamide 

Relevant academic research and scientific papers

4,5-disubstituted-1-hydro-pyrrole(2,3-f)quinoline-2,7,9-tricarboxylate compound and application

The invention discloses a 4,5-disubstituted-1-hydro-pyrrole(2,3-f)quinoline-2,7,9-tricarboxylate compound and analogues or derivatives thereof. The structure of the compound is shown as a formula I, and the structural formula is as shown in the specification. In the formula, R1 and R4 are respectively and independently selected from the following atoms or groups: hydrogen, linear or branched C1-8 alkyl, deuterated linear or branched C1-8 alkyl, aralkyl or substituted aryl radical; R2 is independently selected from the following atoms or groups: halogen, linear or branched C1-8 alkoxy and deuterated linear or branched C1-8 alkoxy; and R3 is independently selected from the following atoms or groups: linear or branched C1-8 alkoxy and deuterated linear or branched C1-8 alkoxy. The compound can serve as a reaction intermediate for synthesizing PQQ (Pyrroloquinoline Quinone), and the oxidizing agent process adopting CAN in the PQQ synthesis in the conventional patent and literature is replaced. Therefore, the whole process is cheap and high-efficiency.

Regioselective ortho-nitration of N-phenyl carboxamides and primary anilines using bismuth nitrate/acetic anhydride

An efficient and one-pot synthetic method for the regioselective ortho-nitration of the N-phenyl carboxamides and primary anilines has been developed by using bismuth nitrate and acetic anhydride as the nitrating reagents. Reaction proceeds at room temperature and results in corresponding ortho-nitrated products in moderate to excellent yields. This method provides an operationally simple, regioselective, and efficient access to synthesize o-nitro anilines under the mild conditions.

ARYL AND HETEROARYL SULPHONAMIDES AS GROWTH HORMONE SECRETAGOGUE RECEPTOR AGONISTS

The present invention therefore provides compounds of formula (I) or pharmaceutically acceptable salts thereof: (I) processes for their preparation, pharmaceutical compositions containing the same and to their use in the treatment of gastrointestinal and other disorders.

Guanidinium nitrate: A novel reagent for aryl nitrations

Nitration of various aromatic compounds utilising guanidinium nitrate in 85% sulfuric acid as a nitrating agent has been studied.

Tricyclic protein kinase inhibitors

This invention provides compounds of Formula (I), where A″, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.

TRICYCLIC PROTEIN KINASE INHIBITORS

This invention provides compounds of Formula (I), where A'', Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.

3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors

This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.

N4-substituted 1-alkoxy-2-acylamino-4-aminobenzenes, process for their preparation and their use

The present invention relates to compounds of the general formula I STR1 wherein R1 denotes formyl or (C1 -C3)-alkylcarbonyl, R2 denotes the group CH2 --CH(A)--B, wherein A represents hydroxyl and B represents hydrogen or methyl, or A represents hydrogen and B represents hydroxymethyl, or the group COO--CH(X)--CH2 --D, wherein X represents hydrogen or methyl and D represents chlorine or bromine, or X represents hydrogen and D represents chloromethyl or bromomethyl, and R3 denotes (C1 -C4)-alkyl, processes for their preparation and their use.

Ozone-mediated Reaction of Anilides and Phenyl Esters with Nitrogen Dioxide: Enhanced Ortho-reactivity and Mechanistic Implications

In the presence of ozone, anilides 1 can be nitrated rapidly with nitrogen dioxide in chloroform at 0 deg C to give a high proportion of ortho-nitro derivatives (ortho:para = 1.2-4.4) in good yields.The phenyl esters 15 can be similarly nitrated on the aromatic ring without significant cleavage of the ester bond, giving a mixture of isomeric nitro derivatives in which the ortho-isomer predominantes (ortho:para = 1.1-1.5).The oridin of the enhanced ortho reactivity is discussed in terms of an electron-transfer process involving the nitrogen trioxide as initial electrophile.

QUADRATIC NONLINEAR OPTICAL ELEMENT

A high-performance quadratic nonlinear optical element which can exhibit a large nonlinear optical effect. The element contains a part which comprises a non-centrosymmetric monoclinic crystal, belonging to the space group Cc and the point group #9, of 4'-nitrobenzylidene-3-alkanoylamino-4-methoxyaniline of formula (I) or derivatives thereof wherein at least part of the hydrogen atoms are deuterated, and which is provided with at least one substantially optically flat surface which admits or transmits rays of light having a large electric oscillation vector component in the direction of the axis of maximum absorption present in the ac face of a nuclear crystal. In formula (I) R represents a C1 or C2 alkyl or haloalkyl.