337355-83-6

Basic information

• Product Name: 5-Isoxazolepropanoic acid, b-hydroxy-a-methylene-3-phenyl-, methyl ester
• CAS NO: 337355-83-6
• Molecular Formula: C14H13NO4
• Molecular Weight: 259.262
• Mol File: 337355-83-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-Isoxazolepropanoic acid, b-hydroxy-a-methylene-3-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Isoxazolepropanoic acid, b-hydroxy-a-methylene-3-phenyl-, methyl ester(337355-83-6)
• EPA Substance Registry System: 5-Isoxazolepropanoic acid, b-hydroxy-a-methylene-3-phenyl-, methyl ester(337355-83-6)

Safety Data

• Hazardous Substances Data: 337355-83-6(Hazardous Substances Data)

Upstream product

• 72418-40-7 3-phenylisoxazole-5-carbaldehyde 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 1189021-51-9 methyl 5-[hydroxy-(3-phenylisoxazol-5-yl)methyl]-3-(4-nitrophenyl)-4,5-dihydroisoxazole-5-carboxylate 
• 1189021-50-8 methyl 5-[hydroxy-(3-phenylisoxazol-5-yl)methyl]-3-(3-nitrophenyl)-4,5-dihydroisoxazole-5-carboxylate 
• 1189021-46-2 methyl 5-[hydroxy-(3-phenylisoxazol-5-yl)methyl]-3-(2-nitrophenyl)-4,5-dihydroisoxazole-5-carboxylate 
• 713137-94-1 2-(3-phenyl-isoxazol-5-ylmethyl)-acrylic acid methyl ester 
• 884537-22-8 2-[2-acetyl-3-oxo-1-(3-phenylisoxazol-5-yl)butyl]acrylic acid methyl ester 
• 503073-45-8 2-[acetoxy-(3-phenyl-isoxazol-5-yl)-methyl]acrylic acid methyl ester 

Relevant articles and documents

Isoxazole-based derivatives from Baylis-Hillman chemistry: Assessment of preliminary hypolipidemic activity

The synthesis of isoxazole-based derivatives utilizing Baylis-Hillman chemistry and results of their preliminary bioevaluation as hypolipidemic agents in triton model are described.

5-Isoxazolecarboxaldehyde: A novel substrate for fast Baylis-Hillman reaction

3-Aryl-5-isoxazolecarboxaldehyde undergoes fast Baylis-Hillman reaction with a variety of activated alkenes to yield the corresponding adducts in excellent yields. Some of the Baylis-Hillman adducts reported herein have been subsequently modified to obtai